Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 72: 116-120, 1992;
8750-7587/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weintraub, Z.
Right arrow Articles by Rigatto, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weintraub, Z.
Right arrow Articles by Rigatto, H.

Journal of Applied Physiology, Vol 72, Issue 1 116-120, Copyright © 1992 by American Physiological Society

ARTICLES

Effects of inhaled oxygen (up to 40%) on periodic breathing and apnea in preterm infants

Z. Weintraub, R. Alvaro, K. Kwiatkowski, D. Cates and H. Rigatto
Department of Pediatrics, University of Manitoba, Winnipeg, Canada.

To discover whether increases in inhaled O2 fraction (FIO2; up to 40%) decrease apnea via an increase in minute ventilation (VE) or a change in respiratory pattern, 15 preterm infants (birth weight 1,300 +/- 354 g, gestational age 29 +/- 2 wk, postnatal age 20 +/- 9 days) breathed 21, 25, 30, 35, and 40% O2 for 10 min in quiet sleep. A nosepiece and a flow-through system were used to measure ventilation. Alveolar PCO2, transcutaneous PO2, and sleep states were also assessed. All infants had periodic breathing with apneas greater than or equal to 3 s. With an increase in FIO2 breathing became more regular and apneas decreased (P less than 0.001). This regularization in breathing was not associated with significant changes in VE. However, the variability of VE, tidal volume, and expiratory and inspiratory times decreased significantly. The results indicate that the more regular breathing observed with small increases in FIO2 was not associated with significant changes in ventilation. The findings suggest that the increased oxygenation decreases apnea and periodicity in preterm infants, not via an increase in ventilation, but through a decrease in breath-to-breath variability of VE.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Khan, M. Qurashi, K. Kwiatkowski, D. Cates, and H. Rigatto
Measurement of the CO2 apneic threshold in newborn infants: possible relevance for periodic breathing and apnea
J Appl Physiol, April 1, 2005; 98(4): 1171 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
N. Simakajornboon, R. C. Beckerman, C. Mack, D. Sharon, and D. Gozal
Effect of Supplemental Oxygen on Sleep Architecture and Cardiorespiratory Events in Preterm Infants
Pediatrics, November 1, 2002; 110(5): 884 - 888.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. J. BERGER, E. M. SKUZA, V. BRODECKY, S. M. CRANAGE, T. M. ADAMSON, and M. H. WILKINSON
Unusual Respiratory Response to Oxygen in an Infant with Repetitive Cyanotic Episodes
Am. J. Respir. Crit. Care Med., June 1, 2000; 161(6): 2107 - 2111.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online