Journal of Applied Physiology AJP: Heart and Circulatory Physiology
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J Appl Physiol 71: 2338-2345, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 6 2338-2345, Copyright © 1991 by American Physiological Society

ARTICLES

Interactions of tumor necrosis factor and granulocytes with pulmonary vascular resistance

I. Mayers, D. Johnson, T. Hurst and T. To
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.

We studied the effects of endotoxin and tumor necrosis factor (TNF-alpha) on hypoxic pulmonary vasoconstriction (HPV) in 12 isolated perfused canine lung lobes. Group 1 lobes were perfused with whole blood, and group 2 lobes were perfused with granulocyte-depleted blood. All lobes were sequentially ventilated with control (35% O2) and hypoxic (3% O2) gas mixtures before and after receiving TNF-alpha. After TNF-alpha, group 2 lost HPV but group 1 retained HPV. After TNF-alpha, total pulmonary vascular resistance decreased in group 2 from 0.085 +/- 0.013 to 0.049 +/- 0.016 cmH2O.ml-1.min (P less than 0.05). We conclude that TNF-alpha acts as a pulmonary vascular vasodilator. In lobes perfused with whole blood, HPV is paradoxically preserved. We speculate that in the presence of cells rich in TNF-alpha receptors, i.e., granulocytes, the circulating levels of TNF-alpha are depressed and full expression of its vascular effects is blunted.


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[Abstract] [Full Text]


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