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J Appl Physiol 71: 1903-1906, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 5 1903-1906, Copyright © 1991 by American Physiological Society

ARTICLES

Human serum catalase decreases endothelial cell injury from hydrogen peroxide

J. A. Leff, M. A. Oppegard, L. S. Terada, E. C. McCarty and J. E. Repine
Department of Medicine, University of Colorado Health Sciences Center, Denver 80262.

Serum from normal human subjects contained variable amounts of catalase activity, which was inhibitable by heat, azide, trichloroacetic acid (TCA), or aminotriazole treatment. Serum also decreased hydrogen peroxide (H2O2) concentrations in vitro and H2O2-mediated injury to cultured endothelial cells. By comparison, heat-, azide-, TCA-, or aminotriazole-treated serum neither decreased H2O2 concentrations in vitro nor reduced H2O2-mediated damage to endothelial cells. We conclude that serum catalase activity can alter H2O2-dependent reactions. We speculate that variations in serum catalase activity may alter individual susceptibility to oxidant-mediated vascular disease or be a factor when added to test systems in vitro.


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