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J Appl Physiol 71: 1403-1408, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 4 1403-1408, Copyright © 1991 by American Physiological Society

ARTICLES

Analysis of pulmonary microvascular permeability after smoke inhalation

T. Isago, S. Noshima, L. D. Traber, D. N. Herndon and D. L. Traber
Department of Anesthesiology, University of Texas Medical Branch, Galveston 77550.

We estimated the reflection (sigma) and filtration coefficients (Kf) in a chronic sheep lung lymphatic preparation after smoke inhalation. Group I (n = 7) sheep were insufflated with cotton smoke and group II animals (n = 5) with room air. After inhalation injury, the lung lymph flow increased nearly four times the baseline value by 24 h after injury. There was a concomitant reduction of sigma (0.81 +/- 0.02 to 0.64 +/- 0.02) and elevation of Kf (0.020 +/- 0.002 to 0.042 +/- 0.009 ml.min-1.mmHg-1); pulmonary capillary pressure was also elevated (13 +/- 1 to 17 +/- 1 mmHg). By 48 h postinjury, sigma and Kf returned toward baseline but pulmonary capillary pressure was still elevated. We determined that 34% of the increase in capillary filtration was attributable to increased capillary pressure and 66% to increased permeability 24 h after inhalation, but 48 h after injury, 75% of the increase in capillary filtration was attributable to increased capillary pressure and 25% to increased permeability. We conclude that the lung edema formation following smoke inhalation is the result of marked increases in both capillary pressure and permeability.


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