Journal of Applied Physiology, Vol 71, Issue 4 1340-1345, Copyright © 1991 by American Physiological Society
Regulation of atrial natriuretic peptide release in normal humans
E. T. Mannix, M. O. Farber, G. R. Aronoff, E. M. Cockerill, T. Ryan, T. Y. Sullivan, S. Carlone, P. Palange, P. Galassetti, P. Serra and al. et
Veterans Affairs Medical Center, Indiana University Medical School, Indianapolis 46202.
Atrial volume, pressure, and heart rate are considered the most important
modulators of atrial natriuretic peptide (ANP) release, although their
relative role is unknown. Continuous positive-pressure breathing in normal
humans may cause atrial pressure and atrial volume to go in opposite
directions (increase and decrease, respectively). We utilized this maneuver
to differentially manipulate atrial volume and atrial pressure and evaluate
the effect on ANP release. Effective filling pressure (atrial pressure
minus pericardial pressure) was also monitored, because this variable has
been proposed as another modulator of ANP secretion. We measured right
atrial (RA) pressure, RA area, esophageal pressure (reflection of
pericardial pressure), and RA and peripheral venous ANP in seven healthy
adult males at rest and during continuous positive-pressure breathing (19
mmHg for 15 min). Continuous positive-pressure breathing decreased RA area
(mean +/- SE, *P less than 0.05) 13.6 +/- 1.1 to 10.5 +/- 0.8* cm2,
increased RA pressure 4 +/- 1 to 16 +/- 1* mmHg, increased esophageal
pressure 2 +/- 1 to 12 +/- 1* mmHg, and increased effective filling
pressure 2 +/- 0 to 4 +/- 1* mmHg. RA ANP increased from 67 +/- 17 to 91
+/- 18* pmol/l and peripheral venous ANP from 43 +/- 4 to 58 +/- 6*
pmol/l.(ABSTRACT TRUNCATED AT 250 WORDS)
