Journal of Applied Physiology AJP: Renal Physiology
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J Appl Physiol 71: 1315-1321, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 4 1315-1321, Copyright © 1991 by American Physiological Society


ARTICLES

Site of action of hypertonic saline in the canine lung

P. D. Sly and C. J. Lanteri
Clinical Sciences Division, Western Australian Research Institute for Child Health, Perth.

The site of action of inhaled hypertonic saline was determined in 8- to 10-wk-old puppies by combining measurements of respiratory mechanics, made during mechanical ventilation and after midexpiratory flow interruptions, with direct measurements of alveolar pressure. Under both control conditions and after inhalation of 10% saline, we were able to partition lung mechanics into components representing the airways and tissue viscoelastic properties. Hypertonic saline challenge altered lung mechanics by increasing airway resistance and did not have any effect on elastic or viscoelastic properties of the lung.


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[Abstract] [Full Text]




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