Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 71: 1245-1260, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Poole, D. C.
Right arrow Articles by Wagner, P. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Poole, D. C.
Right arrow Articles by Wagner, P. D.

Journal of Applied Physiology, Vol 71, Issue 4 1245-1260, Copyright © 1991 by American Physiological Society

ARTICLES

Contribution of excising legs to the slow component of oxygen uptake kinetics in humans

D. C. Poole, W. Schaffartzik, D. R. Knight, T. Derion, B. Kennedy, H. J. Guy, R. Prediletto and P. D. Wagner
Department of Medicine, University of California, San Diego, La Jolla, 92093-0623.

Rates of performing work that engender a sustained lactic acidosis evidence a slow component of pulmonary O2 uptake (VO2) kinetics. This slow component delays or obviates the attainment of a stable VO2 and elevates VO2 above that predicted from considerations of work rate. The mechanistic basis for this slow component is obscure. Competing hypotheses depend on its origin within either the exercising limbs or the rest of the body. To resolve this question, six healthy males performed light nonfatiguing [approximately 50% maximal O2 uptake (VO2max)] and severe fatiguing cycle ergometry, and simultaneous measurements were made of pulmonary VO2 and leg blood flow by thermodilution. Blood was sampled 1) from the femoral vein for O2 and CO2 pressures and O2 content, lactate, pH, epinephrine, norepinephrine, and potassium concentrations, and temperature and 2) from the radial artery for O2 and CO2 pressures, O2 content, lactate concentration, and pH. Two-leg VO2 was thus calculated as the product of 2 X blood flow and arteriovenous O2 difference. Blood pressure was measured in the radial artery and femoral vein. During light exercise, both pulmonary and leg VO2 remained stable from minute 3 to the end of exercise (26 min). In contrast, during severe exercise [295 +/- 10 (SE) W], pulmonary VO2 increased 19.8 +/- 2.4% (P less than 0.05) from minute 3 to fatigue (occurring on average at 20.8 min). Over the same period, leg VO2 increased by 24.2 +/- 5.2% (P less than 0.05). Increases of leg and pulmonary VO2 were highly correlated (r = 0.911), and augmented leg VO2 could account for 86% of the rise in pulmonary VO2.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. R. Chiappa, A. Borghi-Silva, L. F. Ferreira, C. Carrascosa, C. C. Oliveira, J. Maia, A. C. Gimenes, F. Queiroga Jr, D. Berton, E. M. V. Ferreira, et al.
Kinetics of muscle deoxygenation are accelerated at the onset of heavy-intensity exercise in patients with COPD: relationship to central cardiovascular dynamics
J Appl Physiol, May 1, 2008; 104(5): 1341 - 1350.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. M. Jones, J. Fulford, and D. P. Wilkerson
Influence of prior exercise on muscle [phosphorylcreatine] and deoxygenation kinetics during high-intensity exercise in men
Exp Physiol, April 1, 2008; 93(4): 468 - 478.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. M. Jones, D. P. Wilkerson, and J. Fulford
Muscle [phosphocreatine] dynamics following the onset of exercise in humans: the influence of baseline work-rate
J. Physiol., February 1, 2008; 586(3): 889 - 898.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
K. L. Walker, N. R. Saunders, D. Jensen, J. L. Kuk, S.-L. Wong, K. E. Pyke, E. M. Dwyer, and M. E. Tschakovsky
Do vasoregulatory mechanisms in exercising human muscle compensate for changes in arterial perfusion pressure?
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2928 - H2936.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. DeLorey, J. M. Kowalchuk, A. P. Heenan, G. R. duManoir, and D. H. Paterson
Prior exercise speeds pulmonary O2 uptake kinetics by increases in both local muscle O2 availability and O2 utilization
J Appl Physiol, September 1, 2007; 103(3): 771 - 778.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Ferguson, B. J. Whipp, A. J. Cathcart, H. B. Rossiter, A. P. Turner, and S. A. Ward
Effects of prior very-heavy intensity exercise on indices of aerobic function and high-intensity exercise tolerance
J Appl Physiol, September 1, 2007; 103(3): 812 - 822.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Y. Endo, M. Kobayakawa, R. Kinugasa, S. Kuno, H. Akima, H. B. Rossiter, A. Miura, and Y. Fukuba
Thigh muscle activation distribution and pulmonary VO2 kinetics during moderate, heavy, and very heavy intensity cycling exercise in humans
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R812 - R820.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
D. C. Poole and L. F. Ferreira
Muscle-energetic and cardio-pulmonary determinants of exercise tolerance in humans: Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling
Exp Physiol, March 1, 2007; 92(2): 341 - 346.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Burnley, J. H. Doust, and A. M. Jones
Time required for the restoration of normal heavy exercise VO2 kinetics following prior heavy exercise
J Appl Physiol, November 1, 2006; 101(5): 1320 - 1327.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. F. Ferreira, A. J. Harper, and T. J. Barstow
Frequency-domain characteristics and filtering of blood flow following the onset of exercise: implications for kinetics analysis
J Appl Physiol, March 1, 2006; 100(3): 817 - 825.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Kemp, L. F. Ferreira, and T. J. Barstow
Kinetics of muscle oxygen use, oxygen content, and blood flow during exercise
J Appl Physiol, December 1, 2005; 99(6): 2463 - 2469.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. J. Hamann, H. A. Kluess, J. B. Buckwalter, and P. S. Clifford
Blood flow response to muscle contractions is more closely related to metabolic rate than contractile work
J Appl Physiol, June 1, 2005; 98(6): 2096 - 2100.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. S. DeLorey, J. M. Kowalchuk, and D. H. Paterson
Adaptation of pulmonary O2 uptake kinetics and muscle deoxygenation at the onset of heavy-intensity exercise in young and older adults
J Appl Physiol, May 1, 2005; 98(5): 1697 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. F. Ferreira, D. K. Townsend, B. J. Lutjemeier, and T. J. Barstow
Muscle capillary blood flow kinetics estimated from pulmonary O2 uptake and near-infrared spectroscopy
J Appl Physiol, May 1, 2005; 98(5): 1820 - 1828.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
K. Sahlin, J. B. Sorensen, L. B. Gladden, H. B. Rossiter, and P. K. Pedersen
Prior heavy exercise eliminates VO2 slow component and reduces efficiency during submaximal exercise in humans
J. Physiol., May 1, 2005; 564(3): 765 - 773.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. R. Saunders, K. E. Pyke, and M. E. Tschakovsky
Dynamic response characteristics of local muscle blood flow regulatory mechanisms in human forearm exercise
J Appl Physiol, April 1, 2005; 98(4): 1286 - 1296.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Koga, D. C. Poole, T. Shiojiri, N. Kondo, Y. Fukuba, A. Miura, and T. J. Barstow
Comparison of oxygen uptake kinetics during knee extension and cycle exercise
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R212 - R220.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. G. Fawkner and N. Armstrong
Longitudinal changes in the kinetic response to heavy-intensity exercise in children
J Appl Physiol, August 1, 2004; 97(2): 460 - 466.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
H.-Y. Ong, C. S. O'Dochartaigh, S. Lovell, V. H. Patterson, K. Wasserman, D. P. Nicholls, and M. S. Riley
Gas Exchange Responses to Constant Work-Rate Exercise in Patients with Glycogenosis Type V and VII
Am. J. Respir. Crit. Care Med., June 1, 2004; 169(11): 1238 - 1244.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
Y. Fukuba, Y. Ohe, A. Miura, A. Kitano, M. Endo, H. Sato, M. Miyachi, S. Koga, and O. Fukuda
Dissociation between the time courses of femoral artery blood flow and pulmonary VO2 during repeated bouts of heavy knee extension exercise in humans
Exp Physiol, May 1, 2004; 89(3): 243 - 253.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. V. Ocel, L. E. Miller, L. M. Pierson, D. F. Wootten, B. J. Hawkins, J. Myers, and W. G. Herbert
Adaptation of Pulmonary Oxygen Consumption Slow Component Following 6 Weeks of Exercise Training Above and Below the Lactate Threshold in Untrained Men
Chest, December 1, 2003; 124(6): 2377 - 2383.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. R. Day, H. B. Rossiter, E. M. Coats, A. Skasick, and B. J. Whipp
The maximally attainable V.o2 during exercise in humans: the peak vs. maximum issue
J Appl Physiol, November 1, 2003; 95(5): 1901 - 1907.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Endo, S. Tauchi, N. Hayashi, S. Koga, H. B. Rossiter, and Y. Fukuba
Facial cooling-induced bradycardia does not slow pulmonary V.O2 kinetics at the onset of high-intensity exercise
J Appl Physiol, October 1, 2003; 95(4): 1623 - 1631.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. B. Rossiter, S. A. Ward, F. A. Howe, D. M. Wood, J. M. Kowalchuk, J. R. Griffiths, and B. J. Whipp
Effects of dichloroacetate on VO2 and intramuscular 31P metabolite kinetics during high-intensity exercise in humans
J Appl Physiol, September 1, 2003; 95(3): 1105 - 1115.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Carra, R. Candau, S. Keslacy, F. Giolbas, F. Borrani, G. P. Millet, A. Varray, and M. Ramonatxo
Addition of inspiratory resistance increases the amplitude of the slow component of O2 uptake kinetics
J Appl Physiol, June 1, 2003; 94(6): 2448 - 2455.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. M. Pringle, J. H. Doust, H. Carter, K. Tolfrey, and A. M. Jones
Effect of pedal rate on primary and slow-component oxygen uptake responses during heavy-cycle exercise
J Appl Physiol, April 1, 2003; 94(4): 1501 - 1507.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Tordi, S. Perrey, A. Harvey, and R. L. Hughson
Oxygen uptake kinetics during two bouts of heavy cycling separated by fatiguing sprint exercise in humans
J Appl Physiol, February 1, 2003; 94(2): 533 - 541.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. B. Rossiter, S. A. Ward, F. A. Howe, J. M. Kowalchuk, J. R. Griffiths, and B. J. Whipp
Dynamics of intramuscular 31P-MRS Pi peak splitting and the slow components of PCr and O2 uptake during exercise
J Appl Physiol, December 1, 2002; 93(6): 2059 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Burnley, J. H. Doust, D. Ball, and A. M. Jones
Effects of prior heavy exercise on VO2 kinetics during heavy exercise are related to changes in muscle activity
J Appl Physiol, July 1, 2002; 93(1): 167 - 174.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Fukuba, N. Hayashi, S. Koga, and T. Yoshida
VO2 kinetics in heavy exercise is not altered by prior exercise with a different muscle group
J Appl Physiol, June 1, 2002; 92(6): 2467 - 2474.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Kindig, P. McDonough, H. H. Erickson, and D. C. Poole
Effect of L-NAME on oxygen uptake kinetics during heavy-intensity exercise in the horse
J Appl Physiol, August 1, 2001; 91(2): 891 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Borrani, R. Candau, G. Y. Millet, S. Perrey, J. Fuchslocher, and J. D. Rouillon
Is the {V}O2 slow component dependent on progressive recruitment of fast-twitch fibers in trained runners?
J Appl Physiol, June 1, 2001; 90(6): 2212 - 2220.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Williams, H. Carter, A. M. Jones, and J. H. Doust
Oxygen uptake kinetics during treadmill running in boys and men
J Appl Physiol, May 1, 2001; 90(5): 1700 - 1706.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Koga, T. J. Barstow, T. Shiojiri, T. Takaishi, Y. Fukuba, N. Kondo, M. Shibasaki, and D. C. Poole
Effect of muscle mass on {V}O2 kinetics at the onset of work
J Appl Physiol, February 1, 2001; 90(2): 461 - 468.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
J. L Chicharro, J. Hoyos, and A. Lucia
Effects of endurance training on the isocapnic buffering and hypocapnic hyperventilation phases in professional cyclists
Br. J. Sports Med., December 1, 2000; 34(6): 450 - 455.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Carter, A. M. Jones, T. J. Barstow, M. Burnley, C. Williams, and J. H. Doust
Effect of endurance training on oxygen uptake kinetics during treadmill running
J Appl Physiol, November 1, 2000; 89(5): 1744 - 1752.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Burnley, A. M. Jones, H. Carter, and J. H. Doust
Effects of prior heavy exercise on phase II pulmonary oxygen uptake kinetics during heavy exercise
J Appl Physiol, October 1, 2000; 89(4): 1387 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
A. Lucia, J. Hoyos, and J. L Chicharro
The slow component of {V}O2 in professional cyclists
Br. J. Sports Med., October 1, 2000; 34(5): 367 - 374.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
H. Carter, A. M. Jones, T. J. Barstow, M. Burnley, C. A. Williams, and J. H. Doust
Oxygen uptake kinetics in treadmill running and cycle ergometry: a comparison
J Appl Physiol, September 1, 2000; 89(3): 899 - 907.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. L. Hughson, D. D. O'Leary, A. C. Betik, and H. Hebestreit
Kinetics of oxygen uptake at the onset of exercise near or above peak oxygen uptake
J Appl Physiol, May 1, 2000; 88(5): 1812 - 1819.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. E. Bearden and R. J. Moffatt
VO2 kinetics and the O2 deficit in heavy exercise
J Appl Physiol, April 1, 2000; 88(4): 1407 - 1412.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
V. L Billat
{V}O2 slow component and performance in endurance sports
Br. J. Sports Med., April 1, 2000; 34(2): 83 - 85.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. A. Mole and J. J. Hoffmann
VO2 kinetics of mild exercise are altered by RER
J Appl Physiol, December 1, 1999; 87(6): 2097 - 2106.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Koga, T. Shiojiri, M. Shibasaki, N. Kondo, Y. Fukuba, and T. J. Barstow
Kinetics of oxygen uptake during supine and upright heavy exercise
J Appl Physiol, July 1, 1999; 87(1): 253 - 260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. A. Mole, Y. Chung, T. K. Tran, N. Sailasuta, R. Hurd, and T. Jue
Myoglobin desaturation with exercise intensity in human gastrocnemius muscle
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R173 - R180.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. L. Billat, R. Richard, V. M. Binsse, J. P. Koralsztein, and P. Haouzi
The VO2 slow component for severe exercise depends on type of exercise and is not correlated with time to fatigue
J Appl Physiol, December 1, 1998; 85(6): 2118 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. W. Scheuermann, J. M. Kowalchuk, D. H. Paterson, and D. A. Cunningham
O2 uptake kinetics after acetazolamide administration during moderate- and heavy-intensity exercise
J Appl Physiol, October 1, 1998; 85(4): 1384 - 1393.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. N. Proctor, P. H. Shen, N. M. Dietz, T. J. Eickhoff, L. A. Lawler, E. J. Ebersold, D. L. Loeffler, and M. J. Joyner
Reduced leg blood flow during dynamic exercise in older endurance-trained men
J Appl Physiol, July 1, 1998; 85(1): 68 - 75.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I. Langsetmo, G. E. Weigle, M. R. Fedde, H. H. Erickson, T. J. Barstow, and D. C. Poole
VO2 kinetics in the horse during moderate and heavy exercise
J Appl Physiol, October 1, 1997; 83(4): 1235 - 1241.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Koga, T. Shiojiri, N. Kondo, and T. J. Barstow
Effect of increased muscle temperature on oxygen uptake kinetics during exercise
J Appl Physiol, October 1, 1997; 83(4): 1333 - 1338.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Harms, M. A. Babcock, S. R. McClaran, D. F. Pegelow, G. A. Nickele, W. B. Nelson, and J. A. Dempsey
Respiratory muscle work compromises leg blood flow during maximal exercise
J Appl Physiol, May 1, 1997; 82(5): 1573 - 1583.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online