Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 71: 970-976, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Myers, A. C.
Right arrow Articles by Weinreich, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Myers, A. C.
Right arrow Articles by Weinreich, D.

Journal of Applied Physiology, Vol 71, Issue 3 970-976, Copyright © 1991 by American Physiological Society

ARTICLES

Influence of antigen on membrane properties of guinea pig bronchial ganglion neurons

A. C. Myers, B. J. Undem and D. Weinreich
Division of Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore 21224.

The bronchus was isolated from actively sensitized guinea pigs, and the effect of antigen challenge on the excitability of bronchial parasympathetic ganglion neurons was examined with standard intracellular recording techniques. Based on histological examination, we found that mast cells were located near parasympathetic ganglia neurons. Antigen challenge resulted in a loss of mast cell staining and the release of the mast cell-associated mediators, histamine (38 ng/g, approximately 14% of total content) and prostaglandin D2 (PGD2, 118 ng/g wet weight of tissue). Challenging the isolated bronchus with the sensitizing antigen resulted in a transient depolarization (mean 6 mV) of the resting membrane potential of the neurons. Antigen challenge also had a dramatic effect on the accommodative properties of the neurons. Before antigen challenge, two subpopulations of neurons could be differentiated by their response to cathodal current steps: 60% of the cells responded in a "phasic" manner, firing one to six spikes and then accommodated, whereas the balance fired spikes repetitively throughout the current pulse. In phasic firing cells, ovalbumin challenge produced a decrease in accommodation. This was evidenced by a fivefold increase in the number of action potentials elicited during a 500-ms suprathreshold current pulse. The antigen-induced depolarization could be mimicked by histamine, whereas the decrease in accommodation was mimicked by application of PGD2. Leukotriene C4, another mast cell-associated mediator, had no effect on these neuronal properties. These results provide evidence that the immediate hypersensitivity response in guinea pig airways may involve changes in membrane characteristics of bronchial parasympathetic ganglia neurons.


This article has been cited by other articles:


Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. Z. Veres, S. Rochlitzer, M. Shevchenko, B. Fuchs, F. Prenzler, C. Nassenstein, A. Fischer, L. Welker, O. Holz, M. Muller, et al.
Spatial Interactions between Dendritic Cells and Sensory Nerves in Allergic Airway Inflammation
Am. J. Respir. Cell Mol. Biol., November 1, 2007; 37(5): 553 - 561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Yu, M. Kollarik, A. Ouyang, A. C. Myers, and B. J. Undem
Mast cell-mediated long-lasting increases in excitability of vagal C fibers in guinea pig esophagus
Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G850 - G856.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. S. Hazari, J. H. Pan, and A. C. Myers
Nerve growth factor acutely potentiates synaptic transmission in vitro and induces dendritic growth in vivo on adult neurons in airway parasympathetic ganglia
Am J Physiol Lung Cell Mol Physiol, April 1, 2007; 292(4): L992 - L1001.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. S. Jelson, G. M. DeMasi, K. L. Sager, and J. C. Hardwick
Modulation of guinea pig intrinsic cardiac neurons by prostaglandins
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2003; 285(3): R682 - R689.
[Abstract] [Full Text] [PDF]

Home page
 Crit. Rev. Oral Biol. Med.Home page
L. J. Walsh
MAST CELLSAND ORAL INFLAMMATION
Crit. Rev. Oral. Biol. Med., May 1, 2003; 14(3): 188 - 198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. D. Dey
Controlling from within: neurophysiological plasticity of parasympathetic airway neurons
Am J Physiol Lung Cell Mol Physiol, April 1, 2003; 284(4): L578 - L580.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. Kajekar, B. J. Undem, and A. C. Myers
Role of cyclooxygenase activation and prostaglandins in antigen-induced excitability changes of bronchial parasympathetic ganglia neurons
Am J Physiol Lung Cell Mol Physiol, April 1, 2003; 284(4): L581 - L587.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. KAJEKAR, H. K. ROHDE, and A. C. MYERS
The Integrative Membrane Properties of Human Bronchial Parasympathetic Ganglia Neurons
Am. J. Respir. Crit. Care Med., November 15, 2001; 164(10): 1927 - 1932.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. C. Myers
Ca2+ and K+ currents regulate accommodation and firing frequency in guinea pig bronchial ganglion neurons
Am J Physiol Lung Cell Mol Physiol, August 1, 1998; 275(2): L357 - L364.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online