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J Appl Physiol 71: 834-840, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 3 834-840, Copyright © 1991 by American Physiological Society

ARTICLES

How is maximal expiratory flow reduced in canine postpneumonectomy lung growth?

D. Georgopoulos, S. N. Mink, L. Oppenheimer and N. R. Anthonisen
Department of Medicine, University of Manitoba, Winnipeg, Canada.

Six dogs underwent left pneumonectomy (P) at 10 wk of age, while four littermates had a sham operation (C). All dogs were studied at 26 wk of age. Pressure capsules were placed on the right lung to measure lobar alveolar pressures and flows, and a Pitot-static tube was used to measure dynamic intrabronchial pressures. Vital capacity and lung elastic recoil did not differ between P and C. At all lung volumes studied, maximum expiratory flows (Vmax) in P were substantially lower than in C. Choke points in P were located more peripherally than in C. In central airways subjected to the same distending pressure, calculated cross-sectional area was significantly lower in P than in C, indicating different bronchial area-pressure behavior. In P, frictional resistances of the right lower, middle, and cardiac lobes were significantly higher than those in C. These results indicate that the reduction in Vmax in P was greater than would have been expected on the basis of reductions in central airway diameter alone. We calculated that, in the middle vital capacity range, approximately 60% of the decrease in Vmax was due to changes in dynamic central airways properties, and approximately 40% was due to increased lobar frictional resistance related to compensatory growth.


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