Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 71: 1041-1049, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gonzalez, N. C.
Right arrow Articles by Clancy, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gonzalez, N. C.
Right arrow Articles by Clancy, R. L.

Journal of Applied Physiology, Vol 71, Issue 3 1041-1049, Copyright © 1991 by American Physiological Society

ARTICLES

Maximum oxygen uptake and arterial blood oxygenation during hypoxic exercise in rats

N. C. Gonzalez, A. Sokari and R. L. Clancy
Department of Physiology, University of Kansas Medical Center, Kansas City 66103.

The objectives of these experiments were 1) to describe the effect of maximum treadmill exercise on gas exchange, arterial blood gases, and arterial blood oxygenation in rats acclimated for 3 wk to simulated altitude (SA, barometric pressure 370-380 Torr) and 2) to determine the contribution of acid-base changes to the changes in arterial blood oxygenation of hypoxic exercise. Maximum O2 uptake (VO2max) was measured in four groups of rats: 1) normoxic controls run in normoxia (Nx), 2) normoxic controls run in acute hypoxia [AHx inspiratory PO2 (PIO2) approximately 70 Torr], 3) SA rats run in hypoxia (3WHx, PIO2 approximately 70 Torr), and 4) SA rats run in normoxia (ANx). VO2max (ml STPD.min-1.kg-1) was 70.8 +/- 0.9 in Nx, 46.4 +/- 1.9 in AHx, 52.6 +/- 1.1 in 3WHx, and 70.0 +/- 2.4 in ANx. Exercise resulted in acidosis, hypocapnia, and elevated blood lactate in all groups. Although blood lactate increased less in 3WHx and ANx, pH was the same or lower than in Nx and AHx, reflecting the low buffer capacity of SA. In AHx and 3WHx, arterial PO2 increased with exercise; however, O2 saturation of hemoglobin in arterial blood (SaO2) decreased. In vitro measurements of the Bohr shift suggest that SaO2 decreased as a result of a decrease in hemoglobin O2 affinity. The data indicate that several features of hypoxic exercise in this model are similar to those seen in humans, with the exception of the mechanism of decrease in SaO2, which, in humans, appears to be due to incomplete alveolar-capillary equilibration.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
K. K. Henderson, W. McCanse, T. Urano, I. Kuwahira, R. Clancy, and N. C. Gonzalez
Acute vs. chronic effects of elevated hemoglobin O2 affinity on O2 transport in maximal exercise
J Appl Physiol, July 1, 2000; 89(1): 265 - 272.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. C. Gonzalez, R. L. Clancy, Y. Moue, and J.-P. Richalet
Increasing maximal heart rate increases maximal O2 uptake in rats acclimatized to simulated altitude
J Appl Physiol, January 1, 1998; 84(1): 164 - 168.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. Saiki and J. P. Mortola
Effect of 2,4-dinitrophenol on the hypometabolic response to hypoxia of conscious adult rats
J Appl Physiol, August 1, 1997; 83(2): 537 - 542.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. G. Presson Jr., T. M. Todoran, B. J. De Witt, I. F. McMurtry, and W. W. Wagner Jr.
Capillary recruitment and transit time in the rat lung
J Appl Physiol, August 1, 1997; 83(2): 543 - 549.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online