Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 71: 742-748, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Liu, M. Y.
Right arrow Articles by Enhorning, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, M. Y.
Right arrow Articles by Enhorning, G.

Journal of Applied Physiology, Vol 71, Issue 2 742-748, Copyright © 1991 by American Physiological Society

ARTICLES

Pulmonary surfactant will secure free airflow through a narrow tube

M. Y. Liu, L. M. Wang, E. Li and G. Enhorning
Department of Gynecology and Obstetrics, State University of New York, Children's Hospital, Buffalo 14222.

Well functioning pulmonary surfactant is necessary to ensure alveolar stability. It is proposed that surfactant is also required to keep the finest cylindrical airways open, thereby securing an unrestricted flow of air to and from the alveoli. If the surfactant is inadequate in quality or quality there is a risk that liquid will accumulate in the most marrow section of the airway and form a blocking column. To study that possibility special glass capillaries were used. The glass capillaries were heated and extended to make a short section very narrow. In the lumen of that section a minute volume (1 microliter) of liquid was deposited, which formed a blocking column. When pressure was raised on one side of the column, it forced the liquid to move away from the narrow section. Pressure dropped to zero as air could pass, and if the liquid column consisted of calf lung surfactant extract (CLSE), pressure remained at zero because a new liquid column did not form. If, on the other hand, the liquid column consisted of saline solution it would repeatedly reform as soon as it had been pressed out of the capillary's narrow section. The same occurred if the CLSE suspension forming the liquid column was very dilute or contained inhibiting proteins. These observations did not require that the capillary consisted of the material glass; they were also noted when the narrow tube was outlined by epithelium.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. Braun, M. Steinecker, S. Schumacher, and M. Griese
Surfactant function in children with chronic airway inflammation
J Appl Physiol, December 1, 2004; 97(6): 2160 - 2165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Geiser and S. Bastian
Surface-lining layer of airways in cystic fibrosis mice
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1277 - L1285.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.J. Morrell, Y. Arabi, B.R. Zahn, K.C. Meyer, J.B. Skatrud, and M. Safwan Badr
Effect of surfactant on pharyngeal mechanics in sleeping humans: implications for sleep apnoea
Eur. Respir. J., August 1, 2002; 20(2): 451 - 457.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. M. Wright, P. M. Hockey, G. Enhorning, P. Strong, K. B. M. Reid, S. T. Holgate, R. Djukanovic, and A. D. Postle
Altered airway surfactant phospholipid composition and reduced lung function in asthma
J Appl Physiol, October 1, 2000; 89(4): 1283 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
K. C. Meyer, A. Sharma, R. Brown, M. Weatherly, F. R. Moya, J. Lewandoski, and J. J. Zimmerman
Function and Composition of Pulmonary Surfactant and Surfactant-Derived Fatty Acid Profiles Are Altered in Young Adults With Cystic Fibrosis
Chest, July 1, 2000; 118(1): 164 - 174.
[Abstract] [Full Text] [PDF]

Home page
 J Biomater ApplHome page
R. Banerjee and R. R. Puniyani
Exogenous Surfactant Therapy and Mucus Rheology in Chronic Obstructive Airway Diseases
J Biomater Appl, January 1, 2000; 14(3): 243 - 272.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
M. Liu, A. K. Tanswell, and M. Post
Mechanical force-induced signal transduction in lung cells
Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L667 - L683.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. J. Cassidy, D. Halpern, B. G. Ressler, and J. B. Grotberg
Surfactant effects in model airway closure experiments
J Appl Physiol, July 1, 1999; 87(1): 415 - 427.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
N. N. JARJOUR and G. ENHORNING
Antigen-induced Airway Inflammation in Atopic Subjects Generates Dysfunction of Pulmonary Surfactant
Am. J. Respir. Crit. Care Med., July 1, 1999; 160(1): 336 - 341.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. M. HOHLFELD, K. AHLF, G. ENHORNING, K. BALKE, V. J. ERPENBECK, J. PETSCHALLIES, H. G. HOYMANN, H. FABEL, and N. KRUG
Dysfunction of Pulmonary Surfactant in Asthmatics after Segmental Allergen Challenge
Am. J. Respir. Crit. Care Med., June 1, 1999; 159(6): 1803 - 1809.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. HULL, M. SOUTH, P. PHELAN, and K. GRIMWOOD
Surfactant Composition in Infants and Young Children with Cystic Fibrosis
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 161 - 165.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online