Journal of Applied Physiology
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J Appl Physiol 71: 43-49, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 1 43-49, Copyright © 1991 by American Physiological Society

ARTICLES

Cyclooxygenase inhibitors prevent ethchlorvynol-induced injury in rat and rabbit lungs

P. B. Zanaboni, J. D. Bradley, R. O. Webster and T. E. Dahms
Department of Pharmacology, St Louis University School of Medicine, Missouri 63110.

The effect of three chemically dissimilar cyclooxygenase inhibitors on ethchlorvynol-(ECV) induced acute lung injury was studied in isolated buffer-perfused rat and blood-perfused rabbit lungs. ECV caused the microvascular fluid filtration coefficient (Kf) to increase by greater than threefold in the rat lungs and twofold in the rabbit lungs. ECV caused increased pulmonary vascular resistance (PVR) and microvascular pressure measured by the double occlusion technique (Pdo) compared with the vehicle control group in the rat experiments. However, ECV had no effect on PVR or Pdo in the rabbit experiments. Pretreatment with the cyclooxygenase inhibitors indomethacin, ibuprofen, and meclofenamate prevented the increase in microvascular permeability in both the rat and rabbit lung preparations. The cyclooxygenase inhibitors also prevented the ECV-induced PVR and Pdo increases in the rat lungs but had no effect on PVR or Pdo in the rabbit lungs. These results indicate that cyclooxygenase products of arachidonate metabolism mediate the ECV-induced Kf increase in both isolated rat and rabbit lungs.


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