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J Appl Physiol 71: 352-358, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 1 352-358, Copyright © 1991 by American Physiological Society

ARTICLES

Protection from hyperbaric oxidant stress by administration of buthionine sulfoximine

K. H. Komadina, C. A. Duncan, C. L. Bryan and S. G. Jenkinson
Lung Metabolic Unit, University of Texas Health Science Center, San Antonio.

To explore the role of glutathione in protecting rats from hyperbaric hyperoxia, we administered buthionine sulfoximine (BSO) to block gamma-glutamyl cysteine synthase activity and decrease tissue glutathione synthesis. We then exposed these animals and their vehicle-treated matched controls to 100% oxygen at 4 ATA or room air at 1 ATA. After BSO treatment, glutathione concentrations in air-exposed controls decreased 62% in lung, 76% in liver, 28% in brain, and 62% in plasma. Paradoxically, BSO-treated rats were protected from hyperbaric hyperoxia. The BSO-treated animals seized significantly later and had a markedly prolonged time of survival compared with the vehicle-treated controls. We conclude that BSO treatment protects rats from hyperbaric hyperoxia, despite its effects of lowering plasma and tissue glutathione concentrations. This protection may be related to a direct effect of the compound in decreasing free radical-mediated tissue injury, increasing tissue antioxidant defenses, or increasing seizure threshold.


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