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J Appl Physiol 71: 30-36, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 71, Issue 1 30-36, Copyright © 1991 by American Physiological Society

ARTICLES

O2 and rat pulmonary artery tone: effects of endothelium, Ca2+, cyanide, and monocrotaline

R. Mathew, T. Burke-Wolin, M. H. Gewitz and M. S. Wolin
Department of Pediatrics, New York Medical College, Valhalla 10595.

The present study examines the influence of the endothelium (E), Ca2+ concentration, cyanide and monocrotaline (MCT) pretreatment on the responses of isolated rat hilar pulmonary arterial rings (PA) to hypoxia. In PA precontracted with phenylephrine, hypoxia induced an initial E-dependent relaxation phase followed by an E-independent transient contraction and a final relaxation. An increase in Ca2+ concentration from 1.5 to 2.5 mM produced an E-dependent reduction in tone generation under O2 and a significant enhancement of the hypoxia-elicited initial relaxation and the transient contractile responses. Addition of cyanide (0.1 mM) to precontracted PA produced a transient contraction similar to that caused by hypoxia. Preincubation with cyanide led to inhibition of tone generation and abolition of the contraction to hypoxia. However, the final relaxation response to hypoxia was not inhibited by cyanide. Thus, hypoxia produces an E-independent contraction via a mechanism that appears also to be activated by cyanide, and this response is not altered by MCT. The endothelium alters the response to hypoxia in a Ca(2+)-dependent manner.


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