Journal of Applied Physiology, Vol 71, Issue 1 197-203, Copyright © 1991 by American Physiological Society

ARTICLES

Additive effects of training and high-fat diet on energy metabolism during exercise

B. Simi, B. Sempore, M. H. Mayet and R. J. Favier
Laboratoire de Physiologie, Faculte de Medecine, Unite de Recherche Associee 1341 Centre National de la Recherche Scientifique, Lyon, France.

This study was conducted to obtain additional information about the adaptations after 12 wk of high-fat diet (HFD) per se or HFD combined with endurance training in the rat using a two [diet: carbohydrate (CHO) or HFD] by two (training: sedentary or trained) by two (condition at death: rested or exercised) factorial design. Adaptation to prolonged HFD increases maximal O2 uptake (VO2max; 13%, P less than 0.05) and submaximal running endurance (+64%, P less than 0.05). This enhancement in exercise capacity could be attributed to 1) an increase in skeletal muscle aerobic enzyme activities (3-hydroxyacyl-CoA dehydrogenase and citrate synthase in soleus and red quadriceps) or 2) a decrease in liver glycogen breakdown in response to 1 h exercise at 80% VO2max. When training is superimposed to HFD, the most prominent finding provided by this study is that the diet-induced effects are cumulative with the well-known training effect on VO2max, exercise endurance, oxidative capacity of red muscle, and metabolic responses to exercise, with a further reduction in liver glycogen breakdown.

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