Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 70: 2587-2596, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guy, H. J.
Right arrow Articles by West, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guy, H. J.
Right arrow Articles by West, J. B.

Journal of Applied Physiology, Vol 70, Issue 6 2587-2596, Copyright © 1991 by American Physiological Society

ARTICLES

Maximum expiratory flow-volume curves during short periods of microgravity

H. J. Guy, G. K. Prisk, A. R. Elliott and J. B. West
Department of Medicine, University of California, San Diego, La Jolla 92093.

To elucidate the effect of normal gravitation on the shape of the maximum expiratory flow-volume (MEFV) curve, we studied nine normal subjects in a National Aeronautics and Space Administration microgravity research aircraft. They performed multiple MEFV maneuvers at 0, 1, and approximately 2 G. The MEFV curves for each subject were filtered, aligned at residual volume, and ensemble averaged to produce an average MEFV curve for each state, allowing differences to be studied. Most subjects showed a decrease in the forced vital capacity at 0 G, which we attribute to an increased intrathoracic blood volume. In most of these subjects, the mean lung volume associated with a given flow was lower at 0 G over about the upper half of the vital capacity. This is similar to the change previously reported during headout immersion and is consistent with the known effect of engorgement of the lung with blood on elastic recoil. There were also consistent but highly individual changes in the position and magnitude of detailed features of the curve, the individual patterns being similar to those previously reported on transition from the erect to the supine position. This supports the idea that the location and motion of choke points that determine the detailed individual configuration of MEFV curves can be significantly influenced by gravitational forces, presumably via the effects of change in longitudinal tension on local airway pressure-diameter behavior and thus wave speed.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
I. Frerichs, T. Dudykevych, J. Hinz, M. Bodenstein, G. Hahn, and G. Hellige
Gravity effects on regional lung ventilation determined by functional EIT during parabolic flights
J Appl Physiol, July 1, 2001; 91(1): 39 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. K. Prisk
Physiology of a Microgravity Environment: Invited Review: Microgravity and the lung
J Appl Physiol, July 1, 2000; 89(1): 385 - 396.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A.-M. Lauzon, G. K. Prisk, A. R. Elliott, S. Verbanck, M. Paiva, and J. B. West
Paradoxical helium and sulfur hexafluoride single-breath washouts in short-term vs. sustained microgravity
J Appl Physiol, March 1, 1997; 82(3): 859 - 865.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online