| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 70, Issue 6 2395-2400, Copyright © 1991 by American Physiological Society
ARTICLES |
M. Goiny, H. Lagercrantz, M. Srinivasan, U. Ungerstedt and Y. Yamamoto
Nobel Institute for Neurophysiology, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden.
A wide variety of neuroactive substances have been suggested to be involved in the respiratory depression observed in response to severe hypoxia. By use of the technique of microdialysis, the release of dopamine (DA) was measured in the nucleus tractus solitarii during severe hypoxic provocations (6% O2 in N2) in the adult pentobarbital-anesthetized rabbit. DA release was analyzed by high-performance liquid chromatography with electrochemical detection. Such hypoxic provocations caused pronounced phase of depression in the phrenic nerve activity and enhanced release of DA. After bilateral carotid sinus nerve denervation, acute severe hypoxia did not give rise to enhanced release of DA or to phrenic nerve depression. Mild hypoxic (9% or 12% O2 in N2) or hypercapnic (6% CO2) stimuli resulted in an increased phrenic nerve activity without any concomitant changes in DA release. Decerebration at the midcollicular level in rabbits prevented an enhanced release of DA in the nucleus tractus solitarii during severe hypoxia. The results suggest that 1) DA is involved in the central ventilatory response to severe hypoxia, 2) not only the initial excitatory but also the second depressive phase in response to severe hypoxia is mediated partially by the peripheral chemoreceptors, and 3) the depressive phase is dependent on intact connections from suprapontine structures.
This article has been cited by other articles:
|
|
 |
|
  J. Prieto-Lloret, D. F. Donnelly, A. J. Rico, R. Moratalla, C. Gonzalez, and R. J. Rigual Hypoxia transduction by carotid body chemoreceptors in mice lacking dopamine D2 receptors J Appl Physiol, October 1, 2007; 103(4): 1269 - 1275. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Vincent, A. E. Waddell, M. G. Caron, J. K. L. Walker, and J. T. Fisher A murine model of hyperdopaminergic state displays altered respiratory control FASEB J, May 1, 2007; 21(7): 1463 - 1471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. C. Solomon Ionotropic excitatory amino acid receptors in pre-Botzinger complex play a modulatory role in hypoxia-induced gasping in vivo J Appl Physiol, May 1, 2004; 96(5): 1643 - 1650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Hafstrom, J. Milerad, and H. W. Sundell Prenatal Nicotine Exposure Blunts the Cardiorespiratory Response to Hypoxia in Lambs Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1544 - 1549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Kline, K. N. Takacs, E. Ficker, and D. L. Kunze Dopamine Modulates Synaptic Transmission in the Nucleus of the Solitary Tract J Neurophysiol, November 1, 2002; 88(5): 2736 - 2744. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Cohen, Z.-Y. Han, R. Grailhe, J. Gallego, C. Gaultier, J.-P. Changeux, and H. Lagercrantz beta 2 nicotinic acetylcholine receptor subunit modulates protective responses to stress: A receptor basis for sleep-disordered breathing after nicotine exposure PNAS, October 1, 2002; 99(20): 13272 - 13277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. H. Barros and L. G. S. Branco Central dopamine modulates anapyrexia but not hyperventilation induced by hypoxia J Appl Physiol, March 1, 2002; 92(3): 975 - 981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Huey, M. J. Low, M. A. Kelly, R. Juarez, J. M. Szewczak, and F. L. Powell Ventilatory responses to acute and chronic hypoxia in mice: effects of dopamine D2 receptors J Appl Physiol, September 1, 2000; 89(3): 1142 - 1150. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Curran, J. R. Rodman, P. R. Eastwood, K. S. Henderson, J. A. Dempsey, and C. A. Smith Ventilatory responses to specific CNS hypoxia in sleeping dogs J Appl Physiol, May 1, 2000; 88(5): 1840 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Telgkamp and J.-M. Ramirez Differential Responses of Respiratory Nuclei to Anoxia in Rhythmic Brain Stem Slices of Mice J Neurophysiol, November 1, 1999; 82(5): 2163 - 2170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Dwinell and F. L. Powell Chronic hypoxia enhances the phrenic nerve response to arterial chemoreceptor stimulation in anesthetized rats J Appl Physiol, August 1, 1999; 87(2): 817 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. V. SMITH, C.-S. LI, and B. J. DAVIS Excitatory and Inhibitory Modulation of Taste Responses in the Hamster Brainstem Ann. N.Y. Acad. Sci., November 30, 1998; 855(1): 450 - 456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Johnson, S. M. Johnson, and G. S. Mitchell Catecholaminergic modulation of respiratory rhythm in an in vitro turtle brain stem preparation J Appl Physiol, July 1, 1998; 85(1): 105 - 114. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
