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J Appl Physiol 70: 2368-2377, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 70, Issue 6 2368-2377, Copyright © 1991 by American Physiological Society

ARTICLES

Intrathoracic accumulation of 111In-labeled neutrophils in guinea pigs in response to PAF

U. Hultkvist-Bengtsson, G. P. Anderson and J. Morley
Preclinical Research, Sandoz, Basel, Switzerland.

The intrathoracic content of neutrophils, labeled with 111In-oxine has been measured in the anesthetized guinea pig by using an automated isotope-monitoring system. Intravenous infusion of platelet-activating factor (PAF; 5.6, 10, or 18 ng.kg-1.min-1 over 5 min) caused a dose-related abrupt intrathoracic accumulation of neutrophils, which dispersed from the thorax within 20 min. Repetition of this procedure after 1 h gave responses of comparable magnitude and duration. Anti-platelet antiserum pretreatment did not influence the response of neutrophils to PAF. Iloprost infusion (10 ng.kg-1.min-1 over 15 min) did not affect the response of neutrophils to PAF, whereas accumulation of radiolabeled platelets in the lung was totally suppressed by this dose. Intrathoracic accumulation of neutrophils in response to PAF can be considered to be independent of platelet activation.


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