Journal of Applied Physiology
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J Appl Physiol 70: 2145-2154, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 70, Issue 5 2145-2154, Copyright © 1991 by American Physiological Society

ARTICLES

Alveolar air-tissue interface and nuclear magnetic resonance behavior of lung

A. G. Cutillo, K. Ganesan, D. C. Ailion, A. H. Morris, C. H. Durney, S. C. Symko and R. A. Christman
Department of Internal Medicine, University of Utah, Salt Lake City.

Inflated lungs are characterized by a short nuclear magnetic resonance (NMR) free induction decay (rapid disappearance of NMR signal), likely due to internal (tissue-induced) magnetic field inhomogeneity produced by the alveolar air-tissue interface. This phenomenon can also be detected using temporally symmetric and asymmetric NMR spin-echo sequences; these sequences generate a pair of NMR images from which a difference signal (delta) is obtained (reflecting the signal from lung water experiencing the air-tissue interface effect). We measured delta in normal excised rat lungs at inflation pressures of 0-30 cmH2O for asymmetry times (a) of 1-6 ms. Delta was low in degassed lungs and increased markedly with alveolar opening when measured at a = 6 ms (delta 6 ms); delta 6 ms varied little during the rest of the inflation-deflation cycle. Delta 1 ms (a = 1 ms) did not vary significantly on inflation and deflation. Measurements of delta at a = 3 and 5 ms generally lay between those of delta 1 ms and delta 6 ms. These findings, which are consistent with theoretical predictions, suggest that measurements of delta at appropriate asymmetry times are particularly sensitive to alveolar opening and may provide a means of distinguishing alveolar recruitment from alveolar distension in the pressure-volume behavior of the lung.


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