Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 70: 1950-1956, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Martins, M. A.
Right arrow Articles by Drazen, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Martins, M. A.
Right arrow Articles by Drazen, J. M.

Journal of Applied Physiology, Vol 70, Issue 5 1950-1956, Copyright © 1991 by American Physiological Society

ARTICLES

Capsaicin-induced release of tachykinins: effects of enzyme inhibitors

M. A. Martins, S. A. Shore and J. M. Drazen
Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215.

We studied the effects of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE) inhibition on the airway responses and the recovery of endogenously released substance P- and neurokinin A-like immunoreactivities (SP-LI and NKA-LI) after tracheal injection of capsaicin in isolated guinea pig lungs superfused through the trachea. Capsaicin in doses from 10(-10) to 10(-7) mol induced a dose-dependent increase in airway opening pressure and release of SP-LI and NKA-LI. Airway opening pressure changes and the recovery of SP-LI and NKA-LI were significantly greater in lungs superfused with the NEP inhibitor SCH 32615 than in control lungs. ACE inhibition with captopril did not increase the mechanical response or the recovery of SP-LI compared with lungs not receiving captopril. In lungs from guinea pigs pretreated with high doses of capsaicin 7-10 days before study, a regimen designed to deplete endogenous tachykinins, there was a significant decrease in the content and release of NKA-LI and SP-LI. There were no detectable airway effects of acute capsaicin infusion even after doses of 10(-5) mol. Because NEP is important in modulating the airway effects of endogenously released tachykinins after tracheal infusion of capsaicin, but ACE is not, it seems likely that tracheal administration of capsaicin releases tachykinins from epithelial rather than endothelial loci.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
Z.-X. Wu, Q. H. Yang, T. Ruan, and L.-Y. Lee
Influence of maturation on constrictive response to stimulation of C-fiber afferents in isolated guinea pig airways
Am J Physiol Lung Cell Mol Physiol, July 1, 2004; 287(1): L168 - L175.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. D. T. Q. S. Lopes, G. S. Alvarenga, R. Quiles, M. B. Dorna, J. E. Vieira, M. Dolhnikoff, and M. A. Martins
Pulmonary responses to tracheal or esophageal acidification in guinea pigs with airway inflammation
J Appl Physiol, September 1, 2002; 93(3): 842 - 847.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z.-X. Wu, R. F. Morton, and L.-Y. Lee
Role of tachykinins in ozone-induced airway hyperresponsiveness to cigarette smoke in guinea pigs
J Appl Physiol, September 1, 1997; 83(3): 958 - 965.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online