Journal of Applied Physiology Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 70: 1928-1932, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lai-Fook, S. J.
Right arrow Articles by Brown, L. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lai-Fook, S. J.
Right arrow Articles by Brown, L. V.

Journal of Applied Physiology, Vol 70, Issue 5 1928-1932, Copyright © 1991 by American Physiological Society

ARTICLES

Effects of electric charge on hydraulic conductivity of pulmonary interstitium

S. J. Lai-Fook and L. V. Brown
Center for Biomedical Engineering, University of Kentucky, Lexington 40506.

The hydraulic conductivity of pulmonary interstitium was measured in a short isolated segment of interstitium surrounding a large pulmonary artery (1-3 mm diam) of the rabbit. The flow rate of the following solutions was measured sequentially: normal saline, polycation protamine sulfate (0.08 mg/ml), cationic dextran (0.1 or 1.5%) or anionic dextran (0.1 or 1.5%), and hyaluronidase (testes, 0.02%) solution. The pH of all solutions was adjusted to 7.35-7.40. The ratios of the flow of protamine sulfate and cationic dextran to that of saline averaged 2.3 +/- 0.92 (SD, n = 7) and 3.0 +/- 1.2 (n = 6), respectively. The anionic dextran-to-saline flow ratio averaged 0.72 +/- 0.28 (n = 13). Flow increased in the presence of positively charged molecules and decreased in the presence of negatively charged molecules. At a lower pH of 5.0-6.0, only 0.1% cationic dextran had an effect on interstitial conductivity. Thus pulmonary interstitium at physiological pH has the properties of a negatively charged membrane. The increased interstitial conductivity caused by the positively charged molecules was not observed after treatment with hyaluronidase. These effects of electric charge on interstitial conductivity were partly attributed to the presence in the interstitium of negatively charged hyaluronan.


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
V. Goransson, C. Johnsson, A. Jacobson, P. Heldin, R. Hallgren, and P. Hansell
Renal hyaluronan accumulation and hyaluronan synthase expression after ischaemia-reperfusion injury in the rat
Nephrol. Dial. Transplant., April 1, 2004; 19(4): 823 - 830.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. HERMANS and A. BERNARD
Lung Epithelium-specific Proteins . Characteristics and Potential Applications as Markers
Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 646 - 678.
[Full Text]

Home page
 J. Appl. Physiol.Home page
X. L. Qiu, L. V. Brown, S. Parameswaran, G. S. Ibbott, and S. J. Lai-Fook
Effect of concentration on albumin diffusion in lung interstitium
J Appl Physiol, August 1, 1998; 85(2): 575 - 583.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online