Journal of Applied Physiology
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J Appl Physiol 70: 1006-1010, 1991;
8750-7587/91 $5.00
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Journal of Applied Physiology, Vol 70, Issue 3 1006-1010, Copyright © 1991 by American Physiological Society

ARTICLES

Stimulation frequency-dependent nonadrenergic noncholinergic airway responses of the guinea pig

C. S. Venugopalan, E. P. Holmes, V. Fucci and A. J. Guthrie
Department of Veterinary Physiology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.

We examined the inhibitory and excitatory components of the nonadrenergic noncholinergic (NANC) innervation of the guinea pig airways by in vivo and in vitro methods. Electrical stimulation of the vagus in chloralose-urethan-anesthetized guinea pigs after cholinergic and adrenergic blockade produced peripheral airway constriction (insufflation pressure) and tracheal relaxation (pouch pressure). Vagal stimulation was applied for 90 s at 5-V pulses of 2-ms duration at frequencies of 5, 15, 25, and 35 Hz in each group (n = 6). The pouch relaxation peaked at 15 Hz. The insufflation pressure was highest at 5 Hz. Field stimulations of the same frequencies were applied on tracheal spirals and lung parenchymal strips. The maximal relaxation of the trachea occurred at 15-35 Hz. The lung parenchymal strip tensions increased almost linearly as the frequency increased from 5 to 35 Hz. The results of the study indicated a frequency-dependent response for both excitatory and inhibitory components of the NANC, which operate at different frequencies for optimal responses.


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E. W. Taylor, D. Jordan, and J. H. Coote
Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in Vertebrates
Physiol Rev, July 1, 1999; 79(3): 855 - 916.
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