Journal of Applied Physiology, Vol 70, Issue 2 900-906, Copyright © 1991 by American Physiological Society

ARTICLES

Hormonal, electrolyte, and renal responses to exercise are intensity dependent

B. J. Freund, E. M. Shizuru, G. M. Hashiro and J. R. Claybaugh
Department of Clinical Investigation, Tripler Army Medical Center, Honolulu, Hawaii 96859-5000.

Previous work indicates that the magnitude and direction of renal responses to exercise depend on the exercise intensity. To examine mechanisms responsible for these findings, renal and hormonal responses were studied in eight healthy male subjects (29.6 +/- 1.9 yr) before and immediately after four 20-min bouts of submaximal exercise (cycle ergometry) at work loads representing 25, 40, 60, and 80% of maximal oxygen consumption. Urine flow, osmotic clearance, glomerular filtration rate, and sodium excretion (UNa+V) all tended to rise at the 25% work load but were markedly reduced at the higher work intensities. Changes in urine flow paralleled changes in glomerular filtration rate (r = 0.91). Plasma vasopressin (ADH), aldosterone, and plasma renin activity tended to increase progressively with increases in work load, with the increases for all hormones reaching statistical significance when the level of exercise reached greater than or equal to 60% of maximal oxygen consumption. However, atrial natriuretic peptide was elevated (P less than 0.05) at all work loads from greater than 1.6-fold of control levels at the 25% work load to greater than 7-fold at the 80% work load. The increase in urine flow (6 of 8 subjects) and UNa+V (7 of 8 subjects) may be due to the increase in atrial natriuretic peptide and/or a 10% suppression (P less than 0.05) of ADH at the 25% work load.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				M. H. Rosner and J. Kirven Exercise-Associated Hyponatremia Clin. J. Am. Soc. Nephrol., January 1, 2007; 2(1): 151 - 161. [Abstract] [Full Text] [PDF]

				J. R. Poortmans and M. Ouchinsky Glomerular Filtration Rate and Albumin Excretion After Maximal Exercise in Aging Sedentary and Active Men J. Gerontol. A Biol. Sci. Med. Sci., November 1, 2006; 61(11): 1181 - 1185. [Abstract] [Full Text] [PDF]

				C. M. Maresh, C. L. Gabaree-Boulant, L. E. Armstrong, D. A. Judelson, J. R. Hoffman, J. W. Castellani, R. W. Kenefick, M. F. Bergeron, and D. J. Casa Effect of hydration status on thirst, drinking, and related hormonal responses during low-intensity exercise in the heat J Appl Physiol, July 1, 2004; 97(1): 39 - 44. [Abstract] [Full Text] [PDF]

				A. P. Heenan, L. A. Wolfe, G. A. L. Davies, and M. J. McGrath Effects of human pregnancy on fluid regulation responses to short-term exercise J Appl Physiol, December 1, 2003; 95(6): 2321 - 2327. [Abstract] [Full Text]

				N. S. Stachenfeld and D. L. Keefe Estrogen effects on osmotic regulation of AVP and fluid balance Am J Physiol Endocrinol Metab, October 1, 2002; 283(4): E711 - E721. [Abstract] [Full Text] [PDF]

				W. L. Calzone, C. Silva, D. L. Keefe, and N. S. Stachenfeld Progesterone does not alter osmotic regulation of AVP Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2001; 281(6): R2011 - R2020. [Abstract] [Full Text] [PDF]

				N. S. Stachenfeld, A. E. Splenser, W. L. Calzone, M. P. Taylor, and D. L. Keefe Genome and Hormones: Gender Differences in Physiology: Selected Contribution: Sex differences in osmotic regulation of AVP and renal sodium handling J Appl Physiol, October 1, 2001; 91(4): 1893 - 1901. [Abstract] [Full Text] [PDF]

				J. R. Claybaugh, A. K. Sato, L. K. Crosswhite, and L. H. Hassell Effects of time of day, gender, and menstrual cycle phase on the human response to a water load Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R966 - R973. [Abstract] [Full Text] [PDF]

				A. Takamata, H. Nose, T. Kinoshita, M. Hirose, T. Itoh, and T. Morimoto Effect of acute hypoxia on vasopressin release and intravascular fluid during dynamic exercise in humans Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R161 - R168. [Abstract] [Full Text] [PDF]

				T. Nishiyasu, K. Nagashima, E. R. Nadel, and G. W. Mack Human cardiovascular and humoral responses to moderate muscle activation during dynamic exercise J Appl Physiol, January 1, 2000; 88(1): 300 - 307. [Abstract] [Full Text] [PDF]

				W. B. Farquhar and W. L. Kenney Age and renal prostaglandin inhibition during exercise and heat stress J Appl Physiol, June 1, 1999; 86(6): 1936 - 1943. [Abstract] [Full Text] [PDF]

				D. S. O'Leary, N. F. Rossi, and P. C. Churchill Substantial cardiac parasympathetic activity exists during heavy dynamic exercise in dogs Am J Physiol Heart Circ Physiol, November 1, 1997; 273(5): H2135 - H2140. [Abstract] [Full Text] [PDF]

				B. Hanel, I. Teunissen, A. Rabol, J. Warberg, and N. H. Secher Restricted postexercise pulmonary diffusion capacity and central blood volume depletion J Appl Physiol, July 1, 1997; 83(1): 11 - 17. [Abstract] [Full Text] [PDF]