Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 70: 695-700, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cuneo, R. C.
Right arrow Articles by Sonksen, P. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cuneo, R. C.
Right arrow Articles by Sonksen, P. H.

Journal of Applied Physiology, Vol 70, Issue 2 695-700, Copyright © 1991 by American Physiological Society

ARTICLES

Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance

R. C. Cuneo, F. Salomon, C. M. Wiles, R. Hesp and P. H. Sonksen
Division of Medicine, United Medical School, Guy's Hospital, London., United Kingdom.

Growth hormone (GH) treatment in adults with GH deficiency increases lean body mass and thigh muscle cross-sectional area. The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily). Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation. Forced expiratory volume in 1 s, vital capacity, and corrected CO gas transfer were within normal limits and did not change with treatment. Mean predicted VO2max, based on height and age, increased from 78.9 to 96.0% in the rhGH group (compared with 78.5 and 85.0% for placebo; P = 0.036). The anaerobic ventilatory threshold increased in the rhGH group (+159 +/- 39 vs. +1 +/- 51 ml/min; P = 0.02). The improvement in VO2max was noted when expressed per kilogram body weight but not lean body mass or thigh muscle area. We conclude that rhGH treatment in adults with GH deficiency improves and normalizes maximal exercise performance and improves submaximal exercise performance and that these changes are related to increases in lean body mass and muscle mass. Improved cardiac output may also contribute to the effect of rhGH on exercise performance.


This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
M. L. Hartman, A. Weltman, A. Zagar, R. L. Qualy, A. R. Hoffman, and G. R. Merriam
Growth Hormone Replacement Therapy in Adults with Growth Hormone Deficiency Improves Maximal Oxygen Consumption Independently of Dosing Regimen or Physical Activity
J. Clin. Endocrinol. Metab., January 1, 2008; 93(1): 125 - 130.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
J. Gibney, M.-L. Healy, and P. H. Sonksen
The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport
Endocr. Rev., October 1, 2007; 28(6): 603 - 624.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
T. A. Florin, G. E. Fryer, T. Miyoshi, M. Weitzman, A. C. Mertens, M. M. Hudson, C. A. Sklar, K. Emmons, A. Hinkle, J. Whitton, et al.
Physical Inactivity in Adult Survivors of Childhood Acute Lymphoblastic Leukemia: A Report from the Childhood Cancer Survivor Study
Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1356 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. M. Wieselthaler, M. Riedl, H. Schima, O. Wagner, W. Waldhausl, E. Wolner, A. Luger, and M. Clodi
Endocrine function is not impaired in patients with a continuous MicroMed-DeBakey axial flow pump
J. Thorac. Cardiovasc. Surg., January 1, 2007; 133(1): 2 - 6.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
B. Saller, A. F Mattsson, P. H Kann, H. P Koppeschaar, J. Svensson, M. Pompen, and M. Koltowska-Haggstrom
Healthcare utilization, quality of life and patient-reported outcomes during two years of GH replacement therapy in GH-deficient adults - comparison between Sweden, The Netherlands and Germany.
Eur. J. Endocrinol., June 1, 2006; 154(6): 843 - 850.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
L. J. Woodhouse, A. Mukherjee, S. M. Shalet, and S. Ezzat
The Influence of Growth Hormone Status on Physical Impairments, Functional Limitations, and Health-Related Quality of Life in Adults
Endocr. Rev., May 1, 2006; 27(3): 287 - 317.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. E. Molitch, D. R. Clemmons, S. Malozowski, G. R. Merriam, S. M. Shalet, M. L. Vance, and for The Endocrine Society's Clinical Guidelines Su
Evaluation and Treatment of Adult Growth Hormone Deficiency: An Endocrine Society Clinical Practice Guideline
J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1621 - 1634.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
E. R Christ, M. H Cummings, M. Stolinski, N. Jackson, P. J Lumb, A. S Wierzbicki, P. H Sonksen, D. L Russell-Jones, and A M. Umpleby
Low-density lipoprotein apolipoprotein B100 turnover in hypopituitary patients with GH deficiency: a stable isotope study.
Eur. J. Endocrinol., March 1, 2006; 154(3): 459 - 466.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. L. Healy, J. Gibney, C. Pentecost, P. Croos, D. L. Russell-Jones, P. H. Sonksen, and A. M. Umpleby
Effects of High-Dose Growth Hormone on Glucose and Glycerol Metabolism at Rest and during Exercise in Endurance-Trained Athletes
J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 320 - 327.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
J. Bollerslev, J. Hallen, K. J Fougner, A. P. Jorgensen, C. Kristo, H. Fagertun, O. Gudmundsen, P. Burman, and T. Schreiner
Low-dose GH improves exercise capacity in adults with GH deficiency: effects of a 22-month placebo-controlled, crossover trial
Eur. J. Endocrinol., September 1, 2005; 153(3): 379 - 387.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Berggren, C. Ehrnborg, T. Rosen, L. Ellegard, B.-A. Bengtsson, and K. Caidahl
Short-Term Administration of Supraphysiological Recombinant Human Growth Hormone (GH) Does Not Increase Maximum Endurance Exercise Capacity in Healthy, Active Young Men and Women with Normal GH-Insulin-Like Growth Factor I Axes
J. Clin. Endocrinol. Metab., June 1, 2005; 90(6): 3268 - 3273.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Agha, B. Rogers, M. Sherlock, P. O'Kelly, W. Tormey, J. Phillips, and C. J. Thompson
Anterior Pituitary Dysfunction in Survivors of Traumatic Brain Injury
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 4929 - 4936.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. R. Christ, M. H. Cummings, N. Jackson, M. Stolinski, P. J. Lumb, A. S. Wierzbicki, P. H. Sonksen, D. L. Russell-Jones, and A. M. Umpleby
Effects of Growth Hormone (GH) Replacement Therapy on Low-Density Lipoprotein Apolipoprotein B100 Kinetics in Adult Patients with GH Deficiency: A Stable Isotope Study
J. Clin. Endocrinol. Metab., April 1, 2004; 89(4): 1801 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. G. Thomas, J. G. Esposito, and S. Ezzat
Exercise Training Benefits Growth Hormone (GH)-Deficient Adults in the Absence or Presence of GH Treatment
J. Clin. Endocrinol. Metab., December 1, 2003; 88(12): 5734 - 5738.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Schibler, R von der Heiden, P Birrer, and P E Mullis
Prospective randomised treatment with recombinant human growth hormone in cystic fibrosis
Arch. Dis. Child., December 1, 2003; 88(12): 1078 - 1081.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
W. Liu, S. G. Thomas, S. L. Asa, N. Gonzalez-Cadavid, S. Bhasin, and S. Ezzat
Myostatin Is a Skeletal Muscle Target of Growth Hormone Anabolic Action
J. Clin. Endocrinol. Metab., November 1, 2003; 88(11): 5490 - 5496.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Gibney, M. L. Healy, M. Stolinski, S. B. Bowes, C. Pentecost, L. Breen, C. McMillan, D. L. Russell-Jones, P. H. Sonksen, and A. M. Umpleby
Effect of Growth Hormone (GH) on Glycerol and Free Fatty Acid Metabolism during Exhaustive Exercise in GH-Deficient Adults
J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1792 - 1797.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
W. L. Isley
Growth Hormone Therapy for Adults: Not Ready for Prime Time?
Ann Intern Med, August 6, 2002; 137(3): 190 - 196.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. H. W. Lange, J. L. Andersen, N. Beyer, F. Isaksson, B. Larsson, M. H. Rasmussen, A. Juul, J. Bulow, and M. Kjar
GH Administration Changes Myosin Heavy Chain Isoforms in Skeletal Muscle But Does Not Augment Muscle Strength or Hypertrophy, Either Alone or Combined with Resistance Exercise Training in Healthy Elderly Men
J. Clin. Endocrinol. Metab., February 1, 2002; 87(2): 513 - 523.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
J. Kallio, U. Pesonen, M. K. Karvonen, M. Kojima, H. Hosoda, K. Kangawa, and M. Koulu
Enhanced Exercise-Induced GH Secretion in Subjects with Pro7 Substitution in the Prepro-NPY
J. Clin. Endocrinol. Metab., November 1, 2001; 86(11): 5348 - 5352.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Colao, C. di Somma, A. Cuocolo, L. Spinelli, N. Tedesco, R. Pivonello, D. Bonaduce, M. Salvatore, and G. Lombardi
Improved Cardiovascular Risk Factors and Cardiac Performance after 12 Months of Growth Hormone (GH) Replacement in Young Adult Patients with GH Deficiency
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 1874 - 1881.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
L.-W. Chu, K. S. L. Lam, S. C. F. Tam, W. J. H. C. Hu, S.-L. Hui, A. Chiu, K.-C. Chiu, and P. Ng
A Randomized Controlled Trial of Low-Dose Recombinant Human Growth Hormone in the Treatment of Malnourished Elderly Medical Patients
J. Clin. Endocrinol. Metab., May 1, 2001; 86(5): 1913 - 1920.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. Sartorio, C. Lafortuna, and M. V. Narici
Physical Performance in Growth Hormone- Deficient Adults
J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1839 - 1839.
[Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
Measures of Submaximal Aerobic Performance Evaluate and Predict Functional Response to Growth Hormone (GH) Treatment in GH-Deficient Adults
J. Clin. Endocrinol. Metab., December 1, 1999; 84(12): 4570 - 4577.
[Abstract] [Full Text]

Home page
 NEJMHome page
M. L. Vance and N. Mauras
Growth Hormone Therapy in Adults and Children
N. Engl. J. Med., October 14, 1999; 341(16): 1206 - 1216.
[Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease . A Statement of the American Thoracic Society and European Respiratory Society
Am. J. Respir. Crit. Care Med., April 1, 1999; 159(4): S2 - 40.
[Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
Y. J. H. Janssen, J. Doornbos, and F. Roelfsema
Changes in Muscle Volume, Strength, and Bioenergetics during Recombinant Human Growth Hormone (GH) Therapy in Adults with GH Deficiency
J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 279 - 284.
[Abstract] [Full Text]

Home page
 Endocr. Rev.Home page
S. M. Shalet, A. Toogood, A. Rahim, and B. M. D. Brennan
The Diagnosis of Growth Hormone Deficiency in Children and Adults
Endocr. Rev., April 1, 1998; 19(2): 203 - 223.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
P. V. Carroll, E. R. Christ the members of Growth Hormone Research Soci, B. A. Bengtsson, L. Carlsson, J. S. Christiansen, D. Clemmons, R. Hintz, K. Ho, Z. Laron, P. Sizonenko, et al.
Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review
J. Clin. Endocrinol. Metab., February 1, 1998; 83(2): 382 - 395.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. C. Cuneo, S. Judd, J. D. Wallace, D. Perry-Keene, H. Burger, S. Lim-Tio, B. Strauss, J. Stockigt, D. Topliss, F. Alford, et al.
The Australian Multicenter Trial of Growth Hormone (GH) Treatment in GH-Deficient Adults
J. Clin. Endocrinol. Metab., January 1, 1998; 83(1): 107 - 116.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Bottinelli, M. Narici, M. A. Pellegrino, B. Kayser, M. Canepari, G. Faglia, and A. Sartorio
Contractile Properties and Fiber Type Distribution of Quadriceps Muscles in Adults with Childhood-Onset Growth Hormone Deficiency
J. Clin. Endocrinol. Metab., December 1, 1997; 82(12): 4133 - 4138.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Cittadini, H. Stromer, D. E. Vatner, J. D. Grossman, S. E. Katz, R. Clark, J. P. Morgan, and P. S. Douglas
Consequences of Growth Hormone Deficiency on Cardiac Structure, Function, and {beta}-Adrenergic Pathway: Studies in Mutant Dwarf Rats
Endocrinology, December 1, 1997; 138(12): 5161 - 5169.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Johannsson, G. Grimby, K. S. Sunnerhagen, and B.-A. Bengtsson
Two Years of Growth Hormone (GH) Treatment Increase Isometric and Isokinetic Muscle Strength in GH-Deficient Adults
J. Clin. Endocrinol. Metab., September 1, 1997; 82(9): 2877 - 2884.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Hornum, D. M. Cooper, J. A. Brasel, A. Bueno, and K. E. Sietsema
Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women
J Appl Physiol, June 1, 1997; 82(6): 1946 - 1951.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
S. E. Kirk, B. J. Gertz, S. H. Schneider, M. L. Hartman, S. S. Pezzoli, J. M. Wittreich, D. A. Krupa, J. R. Seibold, and M. O. Thorner
Effect of Obesity and Feeding on the Growth Hormone (GH) Response to the GH Secretagogue L-692,429 in Young Men
J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1154 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 DTBHome page
Unlicensed uses for growth hormone
DTB, July 1, 1994; 32(7): 53 - 55.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
M. L. Vance
Hypopituitarism
N. Engl. J. Med., June 9, 1994; 330(23): 1651 - 1662.
[Full Text]

Home page
 ScienceHome page
R. Smith, K Cheng, W. Schoen, S. Pong, G Hickey, T Jacks, B Butler, W. Chan, L. Chaung, F Judith, et al.
A nonpeptidyl growth hormone secretagogue
Science, June 11, 1993; 260(5114): 1640 - 1643.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online