Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 70: 223-230, 1991;
8750-7587/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Babb, T. G.
Right arrow Articles by Rodarte, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Babb, T. G.
Right arrow Articles by Rodarte, J. R.

Journal of Applied Physiology, Vol 70, Issue 1 223-230, Copyright © 1991 by American Physiological Society

ARTICLES

Effect of mild-to-moderate airflow limitation on exercise capacity

T. G. Babb, R. Viggiano, B. Hurley, B. Staats and J. R. Rodarte
Methodist Hospital, Baylor College of Medicine, Houston, Texas 77030.

To determine the effect of mild-to-moderate airflow limitation on exercise tolerance and end-expiratory lung volume (EELV), we studied 9 control subjects with normal pulmonary function [forced expired volume in 1 s (FEV1) 105% pred; % of forced vital capacity expired in 1 s (FEV1/FVC%) 81] and 12 patients with mild-to-moderate airflow limitation (FEV1 72% pred; FEV1/FVC % 58) during progressive cycle ergometry. Maximal exercise capacity was reduced in patients [69% of pred maximal O2 uptake (VO2max)] compared with controls (104% pred VO2max, P less than 0.01); however, maximal expired minute ventilation-to-maximum voluntary ventilation ratio and maximal heart rate were not significantly different between controls and patients. Overall, there was a close relationship between VO2max and FEV1 (r2 = 0.62). Resting EELV was similar between controls and patients [53% of total lung capacity (TLC)], but at maximal exercise the controls decreased EELV to 45% of TLC (P less than 0.01), whereas the patients increased EELV to 58% of TLC (P less than 0.05). Overall, EELV was significantly correlated to both VO2max (r = -0.71, P less than 0.001) and FEV1 (r = -0.68, P less than 0.001). This relationship suggests a ventilatory influence on exercise capacity; however, the increased EELV and associated pleural pressures could influence cardiovascular function during exercise. We suggest that the increase in EELV should be considered a response reflective of the effect of airflow limitation on the ventilatory response to exercise.


This article has been cited by other articles:


Home page
 NEJMHome page
R. Casaburi and R. ZuWallack
Pulmonary Rehabilitation for Management of Chronic Obstructive Pulmonary Disease
N. Engl. J. Med., March 26, 2009; 360(13): 1329 - 1335.
[Full Text] [PDF]

Home page
 ChestHome page
M. Bussotti, P. Agostoni, A. Durigato, C. Santoriello, S. Farina, V. Brusasco, and R. Pellegrino
Do Maximum Flow-Volume Loops Collected During Maximum Exercise Test Alter the Main Cardiopulmonary Parameters?
Chest, February 1, 2009; 135(2): 425 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
I. Vogiatzis, G. Stratakos, D. Athanasopoulos, O. Georgiadou, S. Golemati, A. Koutsoukou, I. Weisman, C. Roussos, and S. Zakynthinos
Chest wall volume regulation during exercise in COPD patients with GOLD stages II to IV
Eur. Respir. J., July 1, 2008; 32(1): 42 - 52.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. Ofir, P. Laveneziana, K. A. Webb, Y.-M. Lam, and D. E. O'Donnell
Mechanisms of Dyspnea during Cycle Exercise in Symptomatic Patients with GOLD Stage I Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., March 15, 2008; 177(6): 622 - 629.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
J. A. Guenette, J. D. Witt, D. C. McKenzie, J. D. Road, and A. W. Sheel
Respiratory mechanics during exercise in endurance-trained men and women
J. Physiol., June 15, 2007; 581(3): 1309 - 1322.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
R. Pellegrino, G. Viegi, V. Brusasco, R. O. Crapo, F. Burgos, R. Casaburi, A. Coates, C. P. M. van der Grinten, P. Gustafsson, J. Hankinson, et al.
Interpretative strategies for lung function tests
Eur. Respir. J., November 1, 2005; 26(5): 948 - 968.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
M. R. Miller, J. Hankinson, V. Brusasco, F. Burgos, R. Casaburi, A. Coates, R. Crapo, P. Enright, C. P. M. van der Grinten, P. Gustafsson, et al.
Standardisation of spirometry
Eur. Respir. J., August 1, 2005; 26(2): 319 - 338.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
S Sabapathy, R A Kingsley, D A Schneider, L Adams, and N R Morris
Continuous and intermittent exercise responses in individuals with chronic obstructive pulmonary disease
Thorax, December 1, 2004; 59(12): 1026 - 1031.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
P. T. Pianosi and H. S. Davis
Determinants of Physical Fitness in Children With Asthma
Pediatrics, March 1, 2004; 113(3): e225 - 229.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. Carter, D. B. Holiday, J. Stocks, and B. Tiep
Peak Physiologic Responses to Arm and Leg Ergometry in Male and Female Patients With Airflow Obstruction
Chest, August 1, 2003; 124(2): 511 - 518.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
ATS/ACCP Statement on Cardiopulmonary Exercise Testing
Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 211 - 277.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Corsico, P. Fulgoni, M. Beccaria, M. C. Zoia, G. Barisione, R. Pellegrino, V. Brusasco, and I. Cerveri
Effects of exercise and beta 2-agonists on lung function in chronic obstructive pulmonary disease
J Appl Physiol, December 1, 2002; 93(6): 2053 - 2058.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
E. Crimi, R. Pellegrino, A. Smeraldi, and V. Brusasco
Exercise-induced bronchodilation in natural and induced asthma: effects on ventilatory response and performance
J Appl Physiol, June 1, 2002; 92(6): 2353 - 2360.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
C. Haccoun, A. A. Smountas, W. J. Gibbons, J. Bourbeau, and L. C. Lands
Isokinetic Muscle Function in COPD*
Chest, April 1, 2002; 121(4): 1079 - 1084.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
T. E. Dolmage and R. S. Goldstein
Repeatability of Inspiratory Capacity During Incremental Exercise in Patients With Severe COPD
Chest, March 1, 2002; 121(3): 708 - 714.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M.L. Ayers, R. Mejia, J. Ward, T. Lentine, and D.A. Mahler
Effectiveness of salmeterol versus ipratropium bromide on exertional dyspnoea in COPD
Eur. Respir. J., June 1, 2001; 17(6): 1132 - 1137.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. G. BABB
Breathing He-O2 Increases Ventilation but Does Not Decrease the Work of Breathing during Exercise
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1128 - 1134.
[Abstract] [Full Text]

Home page
 ChestHome page
D. Murciano, A. Ferretti, J. Boczkowski, C. Sleiman, M. Fournier, and J. Milic-Emili
Flow Limitation and Dynamic Hyperinflation During Exercise in COPD Patients After Single Lung Transplantation
Chest, November 1, 2000; 118(5): 1248 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Dempsey and P. D. Wagner
Exercise-induced arterial hypoxemia
J Appl Physiol, December 1, 1999; 87(6): 1997 - 2006.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
R. Dueck, S. Cooper, D. Kapelanski, H. Colt, and J. Clausen
A Pilot Study of Expiratory Flow Limitation and Lung Volume Reduction Surgery*
Chest, December 1, 1999; 116(6): 1762 - 1771.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. Pellegrino, C. Villosio, U. Milanese, G. Garelli, J. R. Rodarte, and V. Brusasco
Breathing during exercise in subjects with mild-to-moderate airflow obstruction: effects of physical training
J Appl Physiol, November 1, 1999; 87(5): 1697 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. D. Johnson, K. C. Beck, R. J. Zeballos, and I. M. Weisman
Advances in Pulmonary Laboratory Testing
Chest, November 1, 1999; 116(5): 1377 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. D. Johnson, I. M. Weisman, R. J. Zeballos, and K. C. Beck
Emerging Concepts in the Evaluation of Ventilatory Limitation During Exercise: The Exercise Tidal Flow-Volume Loop
Chest, August 1, 1999; 116(2): 488 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. S. DELOREY and T. G. BABB
Progressive Mechanical Ventilatory Constraints with Aging
Am. J. Respir. Crit. Care Med., July 1, 1999; 160(1): 169 - 177.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
S. R. McClaran, T. J. Wetter, D. F. Pegelow, and J. A. Dempsey
Role of expiratory flow limitation in determining lung volumes and ventilation during exercise
J Appl Physiol, April 1, 1999; 86(4): 1357 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Mota, P. Casan, F. Drobnic, J. Giner, O. Ruiz, J. Sanchis, and J. Milic-Emili
Expiratory flow limitation during exercise in competition cyclists
J Appl Physiol, February 1, 1999; 86(2): 611 - 616.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Saito, K. Miyamoto, M. Nishimura, A. Aida, H. Saito, I. Tsujino, and Y. Kawakami
Effects of Inhaled Bronchodilators on Pulmonary Hemodynamics at Rest and During Exercise in Patients With COPD
Chest, February 1, 1999; 115(2): 376 - 382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
E. M. TSCHERNKO, E. M. GRUBER, P. JAKSCH, O. JANDRASITS, U. JANTSCH, T. BRACK, H. LAHRMANN, W. KLEPETKO, and T. WANKE
Ventilatory Mechanics and Gas Exchange during Exercise before and after Lung Volume Reduction Surgery
Am. J. Respir. Crit. Care Med., November 1, 1998; 158(5): 1424 - 1431.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. YAN, D. KAMINSKI, and P. SLIWINSKI
Reliability of Inspiratory Capacity for Estimating End-expiratory Lung Volume Changes during Exercise in Patients with Chronic Obstructive Pulmonary Disease
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 55 - 59.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. G. Babb, K. A. Long, and J. R. Rodarte
The Relationship Between Maximal Expiratory Flow and Increases of Maximal Exercise Capacity with Exercise Training
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 116 - 121.
[Abstract] [Full Text]

Home page
 Am. J. Respir. Crit. Care Med.Home page
J. O. BENDITT, S. LEWIS, D. E. WOOD, L. KLIMA, and R. K. ALBERT
Lung Volume Reduction Surgery Improves Maximal O2 Consumption, Maximal Minute Ventilation, O2 Pulse, and Dead Space-to-Tidal Volume Ratio during Leg Cycle Ergometry
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(2): 561 - 566.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
J. R. Rodarte
Invited Editorial on "Detection of expiratory flow limitation during exercise in COPD patients"
J Appl Physiol, March 1, 1997; 82(3): 721 - 722.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. G. Koulouris, I. Dimopoulou, P. Valta, R. Finkelstein, M. G. Cosio, and J. Milic-Emili
Detection of expiratory flow limitation during exercise in COPD patients
J Appl Physiol, March 1, 1997; 82(3): 723 - 731.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
O. BAUERLE, C. A. CHRUSCH, and M. YOUNES
Mechanisms by Which COPD Affects Exercise Tolerance
Am. J. Respir. Crit. Care Med., January 1, 1997; 157(1): 57 - 68.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online