Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 69: 2311-2316, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Isago, T.
Right arrow Articles by Traber, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Isago, T.
Right arrow Articles by Traber, D. L.

Journal of Applied Physiology, Vol 69, Issue 6 2311-2316, Copyright © 1990 by American Physiological Society

ARTICLES

Determination of pulmonary microvascular reflection coefficient in sheep by venous occlusion

T. Isago, L. D. Traber, D. N. Herndon, S. Abdi, K. Fujioka and D. L. Traber
Department of Anesthesiology, University of Texas Medical Branch, Galveston.

We devised a technique that permitted elevation of pulmonary pressures in unanesthetized sheep by occluding their pulmonary veins. Using this technique, we raised pulmonary capillary pressure from a baseline of 13.2 +/- 2.2 to 35.3 +/- 5.1 mmHg. This increased lung lymph flow (from 8.8 +/- 2.7 to 53.1 +/- 13.9 ml/h). We estimated the pulmonary microvascular oncotic reflection coefficient and found it to be 0.82 +/- 0.05 (SD). The filtration coefficient was 0.019 +/- 0.005 ml.mmHg-1.min-1. During the period of increased pressure, the animals had stable arterial pressures and cardiac outputs. None of the animals developed blood coagulation problems. These data illustrate the usefulness of pulmonary venous occlusion to elevate pulmonary microvascular pressure to obtain plasma-to-lymph protein concentration ratios independent of flow, allowing for the calculation of the oncotic reflection coefficient.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
H. Sakurai, R. Johnigan, Y. Kikuchi, M. Harada, L. D. Traber, and D. L. Traber
Effect of reduced bronchial circulation on lung fluid flux after smoke inhalation in sheep
J Appl Physiol, March 1, 1998; 84(3): 980 - 986.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Hinder, M. Booke, L. D. Traber, and D. L. Traber
Nitric oxide and endothelial permeability
J Appl Physiol, December 1, 1997; 83(6): 1941 - 1946.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. W. Klaesner, N. A. Pou, R. E. Parker, C. Finney, and R. J. Roselli
Optical measurement of isolated canine lung filtration coefficients at normal hematocrits
J Appl Physiol, December 1, 1997; 83(6): 1976 - 1985.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
F. HINDER, J. MEYER, M. BOOKE, J. S. EHARDT, J. R. SALSBURY, L. D. TRABER, and D. L. TRABER
Endogenous Nitric Oxide and the Pulmonary Microvasculature in Healthy Sheep and during Systemic Inflammation
Am. J. Respir. Crit. Care Med., May 1, 1997; 157(5): 1542 - 1549.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online