Journal of Applied Physiology AJP: Endocrinology and Metabolism
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 69: 1479-1485, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gratama, J. W.
Right arrow Articles by Kuipers, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gratama, J. W.
Right arrow Articles by Kuipers, J. R.

Journal of Applied Physiology, Vol 69, Issue 4 1479-1485, Copyright © 1990 by American Physiological Society

ARTICLES

Maximal exercise capacity and oxygen consumption of lambs with an aortopulmonary left-to-right shunt

J. W. Gratama, J. J. Meuzelaar, M. Dalinghaus, J. H. Koers, A. J. Werre, W. G. Zijlstra and J. R. Kuipers
Department of Pediatrics, University of Groningen, The Netherlands.

We determined maximal exercise capacity and measured hemodynamics in 10 6-wk-old lambs with an aortopulmonary left-to-right shunt [S, 57 +/- 11%, (SD)] and in 9 control lambs (C) during a graded treadmill test 8 days after surgery. Maximal exercise capacity (3.7 +/- 0.2 km/h and 10 +/- 5% inclination vs. 4.0 +/- 0.9 km/h and 15 +/- 0% inclination, P less than 0.02) and peak oxygen consumption (25 +/- 7 vs. 34 +/- 8 ml O2.min-1.kg-1, P less than 0.02) were both lower in the shunt than in the control lambs. This was due to a lower maximal systemic blood flow in the shunt lambs (271 +/- 38 vs. 359 +/- 71 ml.min-1.kg-1, P less than 0.01). Despite their high maximal left ventricular output, which was higher than in the control lambs (448 +/- 87 vs. 359 +/- 71 ml.min-1.kg-1, P less than 0.05), the left-to-right shunt could not be compensated for during maximal exercise because of a decreased reserve in heart rate (S: 183 +/- 22 to 277 +/- 38 beats/min; C: 136 +/- 25 to 287 +/- 29 beats/min) and in left ventricular stroke volume (S: 1.8 +/- 0.3 to 1.6 +/- 0.4 ml/kg; C: 1.0 +/- 0.3 to 1.3 +/- 0.2 ml/kg). We conclude that exercise capacity of shunt lambs is lower than that of control lambs, despite a good left ventricular performance, because a part of the reserves for increasing the left ventricular output is already utilized at rest.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
G. C. M. Beaufort-Krol, W. G. Zijlstra, J. Takens, M. C. Molenkamp, K. J. Meuzelaar, G. B. Smid, and J. R. G. Kuipers
Lactate kinetics at rest and during exercise in lambs with aortopulmonary shunts
J Appl Physiol, March 1, 1999; 86(3): 832 - 839.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. C. M. Beaufort-Krol, J. Takens, M. C. Molenkamp, G. B. Smid, K. J. Meuzelaar, W. G. Zijlstra, and J. R. G. Kuipers
Increased myocardial lactate oxidation in lambs with aortopulmonary shunts at rest and during exercise
Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1503 - H1512.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online