Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 69: 1442-1450, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kraemer, W. J.
Right arrow Articles by Fleck, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kraemer, W. J.
Right arrow Articles by Fleck, S. J.

Journal of Applied Physiology, Vol 69, Issue 4 1442-1450, Copyright © 1990 by American Physiological Society

ARTICLES

Hormonal and growth factor responses to heavy resistance exercise protocols

W. J. Kraemer, L. Marchitelli, S. E. Gordon, E. Harman, J. E. Dziados, R. Mello, P. Frykman, D. McCurry and S. J. Fleck
Exercise Physiology Division, US Army Research Institute of Environmental, Natick, Massachusetts 01760-5007.

To examine endogenous anabolic hormone and growth factor responses to various heavy resistance exercise protocols (HREPs), nine male subjects performed each of six randomly assigned HREPs, which consisted of identically ordered exercises carefully designed to control for load [5 vs. 10 repetitions maximum (RM)], rest period length (1 vs. 3 min), and total work effects. Serum human growth hormone (hGH), testosterone (T), somatomedin-C (SM-C), glucose, and whole blood lactate (HLa) concentrations were determined preexercise, midexercise (i.e., after 4 of 8 exercises), and at 0, 5, 15, 30, 60, 90, and 120 min postexercise. All HREPs produced significant (P less than 0.05) temporal increases in serum T concentrations, although the magnitude and time point of occurrence above resting values varied across HREPs. No differences were observed for T when integrated areas under the curve (AUCs) were compared. Although not all HREPs produced increases in serum hGH, the highest responses were observed consequent to the H10/1 exercise protocol (high total work, 1 min rest, 10-RM load) for both temporal and time integrated (AUC) responses. The pattern of SM-C increases varied among HREPs and did not consistently follow hGH changes. Whereas temporal changes were observed, no integrated time (AUC) differences between exercise protocols occurred. These data indicate that the release patterns (temporal or time integrated) observed are complex functions of the type of HREPs utilized and the physiological mechanisms involved with determining peripheral circulatory concentrations (e.g., clearance rates, transport, receptor binding). All HREPs may not affect muscle and connective tissue growth in the same manner because of possible differences in hormonal and growth factor release.


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
J. Gibney, M.-L. Healy, and P. H. Sonksen
The Growth Hormone/Insulin-Like Growth Factor-I Axis in Exercise and Sport
Endocr. Rev., October 1, 2007; 28(6): 603 - 624.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Fujita, T. Abe, M. J. Drummond, J. G. Cadenas, H. C. Dreyer, Y. Sato, E. Volpi, and B. B. Rasmussen
Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis
J Appl Physiol, September 1, 2007; 103(3): 903 - 910.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. D. R. Harridge
Plasticity of human skeletal muscle: gene expression to in vivo function
Exp Physiol, September 1, 2007; 92(5): 783 - 797.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
T. Kvorning, M. Andersen, K. Brixen, P. Schjerling, C. Suetta, and K. Madsen
Suppression of testosterone does not blunt mRNA expression of myoD, myogenin, IGF, myostatin or androgen receptor post strength training in humans
J. Physiol., January 15, 2007; 578(2): 579 - 593.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. R. Pierce, B. C. Clark, L. L. Ploutz-Snyder, and J. A. Kanaley
Growth hormone and muscle function responses to skeletal muscle ischemia
J Appl Physiol, December 1, 2006; 101(6): 1588 - 1595.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. V. Reeves, R. R. Kraemer, D. B. Hollander, J. Clavier, C. Thomas, M. Francois, and V. D. Castracane
Comparison of hormone responses following light resistance exercise with partial vascular occlusion and moderately difficult resistance exercise without occlusion
J Appl Physiol, December 1, 2006; 101(6): 1616 - 1622.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. J. Kraemer, B. C. Nindl, J. O. Marx, L. A. Gotshalk, J. A. Bush, J. R. Welsch, J. S. Volek, B. A. Spiering, C. M. Maresh, A. M. Mastro, et al.
Chronic resistance training in women potentiates growth hormone in vivo bioactivity: characterization of molecular mass variants
Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1177 - E1187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Kvorning, M. Andersen, K. Brixen, and K. Madsen
Suppression of endogenous testosterone production attenuates the response to strength training: a randomized, placebo-controlled, and blinded intervention study
Am J Physiol Endocrinol Metab, December 1, 2006; 291(6): E1325 - E1332.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. R. Collier, E. Collins, and J. A. Kanaley
Oral arginine attenuates the growth hormone response to resistance exercise
J Appl Physiol, September 1, 2006; 101(3): 848 - 852.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. A. Meyer
Does blood flow restriction enhance hypertrophic signaling in skeletal muscle?
J Appl Physiol, May 1, 2006; 100(5): 1443 - 1444.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. M. Bamman, R. C. Ragan, J.-s. Kim, J. M. Cross, V. J. Hill, S. C. Tuggle, and R. M. Allman
Myogenic protein expression before and after resistance loading in 26- and 64-yr-old men and women
J Appl Physiol, October 1, 2004; 97(4): 1329 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. Sports. Med.Home page
R J Godfrey, G Whyte, J McCarthy, A Nevill, and A Head
The validity of capillary blood sampling in the determination of human growth hormone concentration during exercise in men
Br. J. Sports Med., October 1, 2004; 38(5): e27 - e27.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
R. R. Kraemer, R. J. Durand, E. O. Acevedo, L. G. Johnson, G. R. Kraemer, E. P. Hebert, and V. D. Castracane
Rigorous Running Increases Growth Hormone and Insulin-Like Growth Factor-I Without Altering Ghrelin
Experimental Biology and Medicine, March 1, 2004; 229(3): 240 - 246.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Zafeiridis, I. Smilios, R. V. Considine, and S. P. Tokmakidis
Serum leptin responses after acute resistance exercise protocols
J Appl Physiol, February 1, 2003; 94(2): 591 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. C. Hymer, W. J. Kraemer, B. C. Nindl, J. O. Marx, D. E. Benson, J. R. Welsch, S. A. Mazzetti, J. S. Volek, and D. R. Deaver
Characteristics of circulating growth hormone in women after acute heavy resistance exercise
Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E878 - E887.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. C. Nindl, W. J. Kraemer, D. R. Deaver, J. L. Peters, J. O. Marx, J. T. Heckman, and G. A. Loomis
LH secretion and testosterone concentrations are blunted after resistance exercise in men
J Appl Physiol, September 1, 2001; 91(3): 1251 - 1258.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. C. Nindl, W. C. Hymer, D. R. Deaver, and W. J. Kraemer
Growth hormone pulsatility profile characteristics following acute heavy resistance exercise
J Appl Physiol, July 1, 2001; 91(1): 163 - 172.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. C. Nindl, W. J. Kraemer, J. O. Marx, P. J. Arciero, K. Dohi, M. D. Kellogg, and G. A. Loomis
Overnight responses of the circulating IGF-I system after acute, heavy-resistance exercise
J Appl Physiol, April 1, 2001; 90(4): 1319 - 1326.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. Dall, K. H. W. Lange, M. Kjær, J. O. L. Jørgensen, J. S. Christiansen, H. Ørskov, and A. Flyvbjerg
No Evidence of Insulin-Like Growth Factor-Binding Protein 3 Proteolysis during a Maximal Exercise Test in Elite Athletes
J. Clin. Endocrinol. Metab., February 1, 2001; 86(2): 669 - 674.
[Abstract] [Full Text]

Home page
 Am. J. Clin. Nutr.Home page
E. F Coyle
Physical activity as a metabolic stressor
Am. J. Clinical Nutrition, August 1, 2000; 72(2): 512S - 520.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Takarada, H. Takazawa, Y. Sato, S. Takebayashi, Y. Tanaka, and N. Ishii
Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans
J Appl Physiol, June 1, 2000; 88(6): 2097 - 2106.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Takarada, Y. Nakamura, S. Aruga, T. Onda, S. Miyazaki, and N. Ishii
Rapid increase in plasma growth hormone after low-intensity resistance exercise with vascular occlusion
J Appl Physiol, January 1, 2000; 88(1): 61 - 65.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. P. Koziris, W. J. Kraemer, S. E. Gordon, T. Incledon, and H. G. Knuttgen
Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise
J Appl Physiol, January 1, 2000; 88(1): 165 - 172.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. J. Kraemer, K. Hakkinen, R. U. Newton, B. C. Nindl, J. S. Volek, M. McCormick, L. A. Gotshalk, S. E. Gordon, S. J. Fleck, W. W. Campbell, et al.
Effects of heavy-resistance training on hormonal response patterns in younger vs. older men
J Appl Physiol, September 1, 1999; 87(3): 982 - 992.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. P. Koziris, R. C. Hickson, R. T. Chatterton Jr., R. T. Groseth, J. M. Christie, D. G. Goldflies, and T. G. Unterman
Serum levels of total and free IGF-I and IGFBP-3 are increased and maintained in long-term training
J Appl Physiol, April 1, 1999; 86(4): 1436 - 1442.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. C. Fry, W. J. Kraemer, and L. T. Ramsey
Pituitary-adrenal-gonadal responses to high-intensity resistance exercise overtraining
J Appl Physiol, December 1, 1998; 85(6): 2352 - 2359.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
W. J. Kraemer, J. S. Volek, J. A. Bush, M. Putukian, and W. J. Sebastianelli
Hormonal responses to consecutive days of heavy-resistance exercise with or without nutritional supplementation
J Appl Physiol, October 1, 1998; 85(4): 1544 - 1555.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. Rajaram, D. J. Baylink, and S. Mohan
Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation and Functions
Endocr. Rev., December 1, 1997; 18(6): 801 - 831.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
A. Mero, H. Miikkulainen, J. Riski, R. Pakkanen, J. Aalto, and T. Takala
Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training
J Appl Physiol, October 1, 1997; 83(4): 1144 - 1151.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Hornum, D. M. Cooper, J. A. Brasel, A. Bueno, and K. E. Sietsema
Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women
J Appl Physiol, June 1, 1997; 82(6): 1946 - 1951.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. S. Volek, W. J. Kraemer, J. A. Bush, T. Incledon, and M. Boetes
Testosterone and cortisol in relationship to dietary nutrients and resistance exercise
J Appl Physiol, January 1, 1997; 82(1): 49 - 54.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online