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J Appl Physiol 69: 1387-1389, 1990;
8750-7587/90 $5.00
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Journal of Applied Physiology, Vol 69, Issue 4 1387-1389, Copyright © 1990 by American Physiological Society


ARTICLES

Centrifugal intensity and duration as countermeasures to soleus muscle atrophy

D. S. D'Aunno, D. B. Thomason and F. W. Booth
Department of Physiology and Cell Biology, University of Texas Medical School, Houston 77225.

Mechanical acceleration is a countermeasure that may be employed to prevent atrophy of slow-twitch muscle during non-weight bearing. In the present study, daily centrifugation of rats for different durations (1 or 2 h) and at different gravitational intensities (1.5 or 2.6 G) was used to test whether mechanical acceleration could ameliorate the atrophy of the soleus muscle induced by non-weight bearing (tail-traction model). The soleus muscle atrophied 32% during 7 days of non-weight bearing without countermeasures. Centrifugation treatment did not completely prevent atrophy relative to precontrol wet weight of the soleus muscle. Non-weight-bearing groups receiving 2-h daily treatments of 1, 1.5, or 2.6 G had 48, 56, and 65%, respectively, of the atrophy observed in the non-weight-bearing-only group compared with the precontrol group. No evidence was obtained that centrifugation at 2.6 G was more effective than exposure to 1 or 1.5 G as a countermeasure to non-weight-bearing-induced atrophy of the soleus muscle.


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