Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 69: 868-874, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stauber, W. T.
Right arrow Articles by Evans, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stauber, W. T.
Right arrow Articles by Evans, W. J.

Journal of Applied Physiology, Vol 69, Issue 3 868-874, Copyright © 1990 by American Physiological Society

ARTICLES

Extracellular matrix disruption and pain after eccentric muscle action

W. T. Stauber, P. M. Clarkson, V. K. Fritz and W. J. Evans
Department of Physiology, West Virginia University Health Science Center, Morgantown 26506.

Pain, stiffness, and indicators of muscle damage occur at different times after eccentric muscle action. After a single bout of maximal resisted lengthening of the elbow flexors, elbow position, pain perception, and indicators of cellular damage were measured. Immediately postexercise, a significant decrease in resting muscle length was observed that continued to 48 h. At this time, an increase in perceived muscle soreness was noted (P less than 0.05), and a biopsy of the biceps brachii revealed mast cell degranulation, separations of the extracellular matrix from myofibers, and increased plasma constituents in the extracellular space. It is proposed that myofiber disruption allows intracellular proteins to escape and extracellular proteins and ions to enter, causing swelling, whereas the disrupted extracellular matrix initiates the inflammatory response, which includes the release of mast cell granules seen at 48 h postexercise. Thus the delayed sensation of pain (soreness) after repeated eccentric muscle actions probably results from inflammation in response to extracellular matrix disruption.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. D. Black, C. P. Elder, A. Gorgey, and G. A. Dudley
High specific torque is related to lengthening contraction-induced skeletal muscle injury
J Appl Physiol, March 1, 2008; 104(3): 639 - 647.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. C. Kostek, Y.-W. Chen, D. J. Cuthbertson, R. Shi, M. J. Fedele, K. A. Esser, and M. J. Rennie
Gene expression responses over 24 h to lengthening and shortening contractions in human muscle: major changes in CSRP3, MUSTN1, SIX1, and FBXO32
Physiol Genomics, September 11, 2007; 31(1): 42 - 52.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
R. M. Crameri, P. Aagaard, K. Qvortrup, H. Langberg, J. Olesen, and M. Kjaer
Myofibre damage in human skeletal muscle: effects of electrical stimulation versus voluntary contraction
J. Physiol., August 15, 2007; 583(1): 365 - 380.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Kano, D. J. Padilla, B. J. Behnke, K. S. Hageman, T. I. Musch, and D. C. Poole
Effects of eccentric exercise on microcirculation and microvascular oxygen pressures in rat spinotrapezius muscle
J Appl Physiol, October 1, 2005; 99(4): 1516 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
T. P. Stein and C. E. Wade
Metabolic Consequences of Muscle Disuse Atrophy
J. Nutr., July 1, 2005; 135(7): 1824S - 1828S.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y. Kano, D. Padilla, K. S. Hageman, D. C. Poole, and T. I. Musch
Downhill running: a model of exercise hyperemia in the rat spinotrapezius muscle
J Appl Physiol, September 1, 2004; 97(3): 1138 - 1142.
[Abstract] [Full Text] [PDF]

Home page
 ptjournalHome page
A. E Barr and M. F Barbe
Pathophysiological Tissue Changes Associated With Repetitive Movement: A Review of the Evidence
Physical Therapy, February 1, 2002; 82(2): 173 - 187.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. M. Lapointe, P. Fremont, and C. H. Cote
Adaptation to lengthening contractions is independent of voluntary muscle recruitment but relies on inflammation
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R323 - R329.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. Stupka, M. A. Tarnopolsky, N. J. Yardley, and S. M. Phillips
Cellular adaptation to repeated eccentric exercise-induced muscle damage
J Appl Physiol, October 1, 2001; 91(4): 1669 - 1678.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. M. Roth, M. A. Rogers;, and W. J. Evans
Interpretation of Muscle Damage From Fixed Tissue Obtained by Needle Biopsy
Am J Physiol Endocrinol Metab, April 1, 2000; 278(4): E754 - E756.
[Full Text]

Home page
 Am J Sports MedHome page
W. H. Montgomery III, M. Pink, and J. Perry
Electromyographic Analysis of Hip and Knee Musculature During Running
Am. J. Sports Med., March 1, 1994; 22(2): 272 - 278.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online