Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 68: 2391-2393, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matsuse, T.
Right arrow Articles by Orimo, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsuse, T.
Right arrow Articles by Orimo, H.

Journal of Applied Physiology, Vol 68, Issue 6 2391-2393, Copyright © 1990 by American Physiological Society

ARTICLES

Effect of endothelin-1 on pulmonary resistance in rats

T. Matsuse, Y. Fukuchi, T. Suruda, T. Nagase, Y. Ouchi and H. Orimo
Department of Geriatrics, Faculty of Medicine, University of Tokyo, Japan.

We examined the effect of endothelin-1 (ET-1), a novel 21-residue vasoconstrictor peptide, on pulmonary resistance (RL) in Wistar rats. The lung volume, tracheal flow, and transpulmonary pressure of tracheotomized and paralyzed rats were measured with a fluid-filled esophageal catheter and a pressure-sensitive body plethysmograph. RL was calculated by the method of von Neergaard. The femoral artery was cannulated to measure the mean arterial blood pressure. Intravenous bolus administration of synthetic ET-1 provoked a dose-dependent increase in RL in rats. The bronchoconstricting effect reached maximum at 500 pmol/kg. This bronchoconstriction was observed in less than 5 min, increased up to 15 min, and was sustained for 60 min. ET-1 increased the mean arterial blood pressure in a dose-dependent manner. We conclude that ET-1 is a hitherto unknown potent bronchoconstrictor that has a sustained effect in vivo. The potential physiological and pathophysiological role of this new peptide in the development of respiratory disease warrants further investigation.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
T. Nagase, T. Aoki, T. Oka, Y. Fukuchi, and Y. Ouchi
ET-1-induced bronchoconstriction is mediated via ETB receptor in mice
J Appl Physiol, July 1, 1997; 83(1): 46 - 51.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. NAGASE, H. KURIHARA, Y. KURIHARA, T. AOKI, Y. FUKUCHI, Y. YAZAKI, and Y. OUCHI
Airway Hyperresponsiveness to Methacholine in Mutant Mice Deficient in Endothelin-1
Am. J. Respir. Crit. Care Med., February 1, 1997; 157(2): 560 - 564.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online