Journal of Applied Physiology
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J Appl Physiol 68: 2274-2279, 1990;
8750-7587/90 $5.00
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Journal of Applied Physiology, Vol 68, Issue 6 2274-2279, Copyright © 1990 by American Physiological Society

ARTICLES

Respiratory mechanics in adult rats hypercapnic in the neonatal period

R. Rezzonico, R. D. Gleed and J. P. Mortola
Department of Physiology, McGill University, Montreal, Quebec, Canada.

Because chronic hypoxia in the neonatal period has long-term effects on the mechanical properties of the respiratory system (S. Okubo and J. P. Mortola, J. Appl. Physiol. 66: 1772-1778, 1989), we asked whether similar effects would occur after neonatal exposure to hypercapnia. Three groups of rats were used. The first was exposed to 7% CO2 in normoxia from day 1 to 7 after birth and then returned to normocapnia (NB-CO2). The second was exposed to the same level and duration of hypercapnia from day 36 to 42, i.e., approximately 2 wk after weaning (AD-CO2). The third was raised in normoxia and normocapnia (control). At approximately 50 days, i.e., 1-2 wk after puberty, the passive mechanical properties of the respiratory system, lung, and chest were measured during artificial ventilation in the anesthetized and paralyzed animal. No differences were observed between AD-CO2 and control. NB-CO2 had higher compliance of the lung (approximately +40%) and respiratory system (+32%) than control or AD-CO2. Average values of resistance of the total respiratory system, lung, and chest wall were consistently lower in NB-CO2 than in control and AD-CO2, although the magnitude and statistical significance of the decrease depended on the method of measurement. In a separate group of NB-CO2, lung compliance was measured during spontaneous breathing, and it averaged 34% more than in control. The exponential constant of the deflation quasi-static pressure-volume curve of the liquid-filled lungs was also significantly higher than in control.(ABSTRACT TRUNCATED AT 250 WORDS)


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