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J Appl Physiol 68: 1755-1757, 1990;
8750-7587/90 $5.00
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Journal of Applied Physiology, Vol 68, Issue 4 1755-1757, Copyright © 1990 by American Physiological Society

ARTICLES

Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

M. L. Waintrub, L. S. Terada, C. J. Beehler, B. O. Anderson, J. A. Leff and J. E. Repine
Webb-Waring Lung Institute, Department of Medicine, University of Colorado, Health Sciences Center, Denver 80262.

Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.




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