Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 68: 1195-1202, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Badr, M. S.
Right arrow Articles by Begle, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Badr, M. S.
Right arrow Articles by Begle, R. L.

Journal of Applied Physiology, Vol 68, Issue 3 1195-1202, Copyright © 1990 by American Physiological Society

ARTICLES

Effect of mechanical loading on expiratory and inspiratory muscle activity during NREM sleep

M. S. Badr, J. B. Skatrud, J. A. Dempsey and R. L. Begle
Medical Service, William S. Middleton Memorial Veterans Administration Hospital, Madison 53705.

We investigated the effect of acute and sustained inspiratory resistive loading (IRL) on the activity of expiratory abdominal muscles (EMGab) and the diaphragm (EMGdi) and on ventilation during wakefulness and non-rapid-eye-movement (NREM) sleep in healthy subjects. EMGdi and EMGab were measured with esophageal and transcutaneous electrodes, respectively. During wakefulness, EMGdi increased in response to acute loading (18 cmH2O.l-1.s) (+23%); this was accompanied by preservation of tidal volume (VT) and minute ventilation (VE). During NREM sleep, no augmentation was noted in EMGdi or EMGab. Inspiratory time (TI) was prolonged (+5%), but this was not sufficient to prevent a decrease in both VT and VE (-21 and -20%, respectively). During sustained loading (12 cmH2O.l-1 s) in NREM sleep, control breaths (C) were compared with the steady-state loaded breaths (SS) defined by breaths 41-50. Steady-state IRL was associated with augmentation of EMGdi (12%) and EMGab (50%). VT returned to control levels, expiratory time shortened, and breathing frequency increased. The net result was the increase in VE above control levels (+5%, P less than 0.01). No change was noted in end-tidal CO2 or O2. We concluded that 1) wakefulness is a prerequisite for immediate load compensation (in its absence, TI prolongation is the only compensatory response) and 2) during sustained IRL, the augmentation of EMGdi and EMGab can lead to complete ventilatory recovery without measurable changes in chemical stimuli.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. A. Rowley, X. Zhou, I. Vergine, M. A. Shkoukani, and M. S. Badr
Influence of gender on upper airway mechanics: upper airway resistance and Pcrit
J Appl Physiol, November 1, 2001; 91(5): 2248 - 2254.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. YOUNES, M. OSTROWSKI, W. THOMPSON, C. LESLIE, and W. SHEWCHUK
Chemical Control Stability in Patients with Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., April 1, 2001; 163(5): 1181 - 1190.
[Abstract] [Full Text]

Home page
 Br J AnaesthHome page
J. A. Loadsman and D. R. Hillman
Anaesthesia and sleep apnoea
Br. J. Anaesth., February 1, 2001; 86(2): 254 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
G. PILLAR, A. MALHOTRA, R. FOGEL, J. BEAUREGARD, R. SCHNALL, and D. P. WHITE
Airway Mechanics and Ventilation in Response to Resistive Loading during Sleep . Influence of Gender
Am. J. Respir. Crit. Care Med., November 1, 2000; 162(5): 1627 - 1632.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
M. Sahin, D. M. Durand, and M. A. Haxhiu
Chronic recordings of hypoglossal nerve activity in a dog model of upper airway obstruction
J Appl Physiol, December 1, 1999; 87(6): 2197 - 2206.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. L. Marcus, G. A. Moreira, O. Bamford, and J. Lutz
Response to inspiratory resistive loading during sleep in normal children and children with obstructive apnea
J Appl Physiol, October 1, 1999; 87(4): 1448 - 1454.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
P. M. SIMON, A. S. ZUROB, W. M. WIES, J. C. LEITER, R. D. HUBMAYR, M. L. JENSEN, and R. W. STROETZ
Entrainment of Respiration in Humans by Periodic Lung Inflations . Effect of State and CO2
Am. J. Respir. Crit. Care Med., September 1, 1999; 160(3): 950 - 960.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
S. Meza, M. Mendez, M. Ostrowski, and M. Younes
Susceptibility to periodic breathing with assisted ventilation during sleep in normal subjects
J Appl Physiol, November 1, 1998; 85(5): 1929 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. BRACK, A. JUBRAN, and M. J. TOBIN
Effect of Resistive Loading on Variational Activity of Breathing
Am. J. Respir. Crit. Care Med., June 1, 1998; 157(6): 1756 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Meza, E. Giannouli, and M. Younes
Control of breathing during sleep assessed by proportional assist ventilation
J Appl Physiol, January 1, 1998; 84(1): 3 - 12.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. A. Smith, K. S. Henderson, L. Xi, C.-M. Chow, P. R. Eastwood, and J. A. Dempsey
Neural-mechanical coupling of breathing in REM sleep
J Appl Physiol, December 1, 1997; 83(6): 1923 - 1932.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online