| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 68, Issue 3 1086-1091, Copyright © 1990 by American Physiological Society
ARTICLES |
J. S. Wyatt, M. Cope, D. T. Delpy, C. E. Richardson, A. D. Edwards, S. Wray and E. O. Reynolds
Department of Paediatrics, University College London, United Kingdom.
Current methods for measuring cerebral blood volume (CBV) in newborn infants are unsatisfactory. A new method is described in which the effect of a small change (5-10%) in arterial oxygen saturation (SaO2) on cerebral oxyhemoglobin [HbO2] and deoxyhemoglobin [Hb] concentration is observed by near-infrared (NIR) spectroscopy. Previous experiments in which the NIR absorption characteristics of HbO2 and Hb and the pathlength of NIR light through the brain were defined allowed changes in [HbO2] and [Hb] to be quantified from the Beer-Lambert law. It is shown here that CBV can then be derived from the expression CBV = (delta[HbO2] - delta[Hb])/(2. delta SaO2.H.R.), where H is the large vessel total hemoglobin concentration and R to the cerebral-to-large vessel hematocrit ratio. Observations on 12 newborn infants with normal brains, born at 25-40 wk of gestation and aged 10-240 h, gave a mean value for CBV of 2.22 +/- 0.40 (SD) ml/100 g, whereas mean CBV was significantly higher 3.00 +/- 1.04 ml/100 g in 10 infants with brain injury born at 24 to 42 wk of gestation and aged 4-168 h (P less than 0.05).
This article has been cited by other articles:
|
|
 |
|
  S. Chakravarti, S. Srivastava, and A. J. C. Mittnacht Near Infrared Spectroscopy (NIRS) in Children Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2008; 12(1): 70 - 79. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Y. Wong, T. S. Leung, T. Austin, M. Wilkinson, J. H. Meek, J. S. Wyatt, and A. M. Walker Impaired Autoregulation in Preterm Infants Identified by Using Spatially Resolved Spectroscopy Pediatrics, March 1, 2008; 121(3): e604 - e611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bennet, V. Roelfsema, J. M. Dean, G. Wassink, G. G. Power, E. C. Jensen, and A. J. Gunn Regulation of cytochrome oxidase redox state during umbilical cord occlusion in preterm fetal sheep Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1569 - R1576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Bennet, V. Roelfsema, P. Pathipati, J. S. Quaedackers, and A. J. Gunn Relationship between evolving epileptiform activity and delayed loss of mitochondrial activity after asphyxia measured by near-infrared spectroscopy in preterm fetal sheep J. Physiol., April 1, 2006; 572(1): 141 - 154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ricci, P. Lombardi, S. Schultz, A. Galindo, E. Coscarella, A. Vasquez, and E. Rosenkranz Near-infrared spectroscopy to monitor cerebral oxygen saturation in single-ventricle physiology J. Thorac. Cardiovasc. Surg., February 1, 2006; 131(2): 395 - 402. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. McLeod, F. Igielman, C. Elwell, M. Cope, and M. Smith Measuring Cerebral Oxygenation During Normobaric Hyperoxia: A Comparison of Tissue Microprobes, Near-Infrared Spectroscopy, and Jugular Venous Oximetry in Head Injury Anesth. Analg., September 1, 2003; 97(3): 851 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chipchase, D. Peebles, and C. Rodeck Severe Preeclampsia and Cerebral Blood Volume Response to Postural Change Obstet. Gynecol., January 1, 2003; 101(1): 86 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. T. van de Ven, W. N. J. M. Colier, M. C. van der Sluijs, B. Oeseburg, P. Vis, and H. Folgering Effects of Acetazolamide and Furosemide on Ventilation and Cerebral Blood Volume in Normocapnic and Hypercapnic Patients With COPD Chest, February 1, 2002; 121(2): 383 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Al-Rawi, P. Smielewski, and P. J. Kirkpatrick Evaluation of a Near-Infrared Spectrometer (NIRO 300) for the Detection of Intracranial Oxygenation Changes in the Adult Head Stroke, November 1, 2001; 32(11): 2492 - 2500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Lovell, A. C. Marshall, C. E. Elwell, M. Smith, and J. C. Goldstone Changes in Cerebral Blood Volume with Changes in Position in Awake and Anesthetized Subjects Anesth. Analg., February 1, 2000; 90(2): 372 - 372. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Hopton, T. S. Walsh, and A. Lee Measurement of cerebral blood volume using near-infrared spectroscopy and indocyanine green elimination J Appl Physiol, November 1, 1999; 87(5): 1981 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H Meek, C. E Elwell, D. C McCormick, A D. Edwards, J. P Townsend, A. L Stewart, and J. S Wyatt Abnormal cerebral haemodynamics in perinatally asphyxiated neonates related to outcome Arch. Dis. Child. Fetal Neonatal Ed., September 1, 1999; 81(2): 110F - 115. [Abstract] [Full Text]
|
|
|
|
|
|
M. Firbank, C. E. Elwell, C. E. Cooper, and D. T. Delpy Experimental and theoretical comparison of NIR spectroscopy measurements of cerebral hemoglobin changes J Appl Physiol, November 1, 1998; 85(5): 1915 - 1921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pellicer, F. Gayá, T. A Stiris, J. Quero, and F. Cabañas Cerebral haemodynamics in preterm infants after exposure to dexamethasone Arch. Dis. Child. Fetal Neonatal Ed., September 1, 1998; 79(2): 123F - 128. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. P. Eiberg, N. H. Secher, and T. V. Schroeder Improved Postischemic Recovery After Peripheral Bypass Surgery Assessed by Near-Infrared Spectroscopy Vascular and Endovascular Surgery, July 1, 1998; 32(4): 361 - 366. [Abstract] [PDF]
|
|
|
|
|
|
B. A. Feet, N. C. Brun, L. Hellstrom-Westas, N. W. Svenningsen, G. Greisen, and O. D. Saugstad Early cerebral metabolic and electrophysiological recovery during controlled hypoxemic resuscitation in piglets J Appl Physiol, April 1, 1998; 84(4): 1208 - 1216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H Meek, L. Tyszczuk, C. E Elwell, and J S Wyatt Cerebral blood flow increases over the first three days of life in extremely preterm neonates Arch. Dis. Child. Fetal Neonatal Ed., January 1, 1998; 78(1): 33F - 37. [Abstract] [Full Text]
|
|
|
|
|
|
G. Chow, I. G. Roberts, A. D. Edwards, A. Lloyd-Thomas, A. Wade, M. J. Elliott, and F. J. Kirkham THE RELATION BETWEEN PUMP FLOW RATE AND PULSATILITY ON CEREBRAL HEMODYNAMICS DURING PEDIATRIC CARDIOPULMONARY BYPASS J. Thorac. Cardiovasc. Surg., October 1, 1997; 114(4): 568 - 577. [Abstract] [Full Text]
|
|
|
|
|
|
P. Smielewski, M. Czosnyka, J. D. Pickard, and P. Kirkpatrick Clinical Evaluation of Near-Infrared Spectroscopy for Testing Cerebrovascular Reactivity in Patients With Carotid Artery Disease Stroke, February 1, 1997; 28(2): 331 - 338. [Abstract] [Full Text]
|
|
|
|
|
|
P. Smielewski, P. Kirkpatrick, P. Minhas, J. D. Pickard, and M. Czosnyka Can Cerebrovascular Reactivity Be Measured With Near-Infrared Spectroscopy? Stroke, December 1, 1995; 26(12): 2285 - 2292. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. Benaron and D. Stevenson Optical time-of-flight and absorbance imaging of biologic media Science, March 5, 1993; 259(5100): 1463 - 1466. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Edwards Protection against hypoxic-ischaemic cerebral injury in the developing brain Perfusion, January 1, 1993; 8(1): 97 - 100. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
