Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 68: 678-686, 1990;
8750-7587/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walker, B. R.
Right arrow Articles by Brizzee, B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walker, B. R.
Right arrow Articles by Brizzee, B. L.

Journal of Applied Physiology, Vol 68, Issue 2 678-686, Copyright © 1990 by American Physiological Society

ARTICLES

Cardiovascular responses to hypoxia and hypercapnia in barodenervated rats

B. R. Walker and B. L. Brizzee
Department of Physiology, University of New Mexico School of Medicine, Albuquerque 87131.

Experiments were performed to examine the role of the arterial baroreceptors in the cardiovascular responses to acute hypoxia and hypercapnia in conscious rats chronically instrumented to monitor systemic hemodynamics. One group of rats remained intact, whereas a second group was barodenervated. Both groups of rats retained arterial chemoreceptive function as demonstrated by augmented ventilation in response to hypoxia. The cardiovascular effects to varying inspired levels of O2 and CO2 were examined and compared between intact and barodenervated rats. No differences between groups were noted in response to mild hypercapnia (5% CO2); however, the bradycardia and reduction in cardiac output observed in intact rats breathing 10% CO2 were eliminated by barodenervation. In addition, hypocapnic hypoxia caused a marked fall in blood pressure and total peripheral resistance (TPR) in barodenervated rats compared with controls. Similar differences in TPR were observed between the groups in response to isocapnic and hypercapnic hypoxia as well. It is concluded that the arterial baroreflex is an important component of the overall cardiovascular responses to both hypercapnic and hypoxic stimuli in the conscious rat.


This article has been cited by other articles:


Home page
 Exp PhysiolHome page
R. Howden, J. T. Lightfoot, S. J. Brown, and I. L. Swaine
The effects of breathing 5% CO2 on human cardiovascular responses and tolerance to orthostatic stress
Exp Physiol, July 1, 2004; 89(4): 465 - 471.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Waters and K. D. Tinworth
Effect of stimulus cycle time on acute respiratory responses to intermittent hypercapnic hypoxia in unsedated piglets
J Appl Physiol, June 1, 2003; 94(6): 2465 - 2474.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Tominaga, T. A. Stekiel, Z. J. Bosnjak, and J. P. Kampine
Contribution of carotid chemoreceptors to mesenteric venoconstriction during acute hypercapnia in rabbits
Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2305 - H2310.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. G. Franchini, V. L. L. Oliveira, and E. M. Krieger
Hemodynamics of Chemoreflex Activation in Unanesthetized Rats
Hypertension, September 1, 1997; 30(3): 699 - 703.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online