Journal of Applied Physiology
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J Appl Physiol 68: 549-553, 1990;
8750-7587/90 $5.00
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Journal of Applied Physiology, Vol 68, Issue 2 549-553, Copyright © 1990 by American Physiological Society

ARTICLES

Endotoxin protection of rats from pulmonary oxygen toxicity: possible cytokine involvement

J. T. Berg, R. C. Allison, V. R. Prasad and A. E. Taylor
Department of Physiology, College of Medicine, University of South Alabama, Mobile 36688.

Treatment with endotoxin protects rats against lung injury during hyperoxia (greater than 98% oxygen at 1 atmosphere absolute for 60 h). This study demonstrates that serum from endotoxin-treated donor rats also protects recipients from oxygen toxicity. Rats treated with serum from saline-treated donors were not protected, and protection was not explained by residual endotoxin in protective sera. Unlike endotoxin-protected rats (where lung antioxidant enzyme activity is elevated after hyperoxia), postexposure superoxide dismutase (SOD) and catalase (CAT) activities in the lungs of serum-protected rats were not affected. Levels of tumor necrosis factor (TNF) and interleukin 1 (IL-1) in protective sera were increased. This study demonstrates that increases in lung SOD and CAT activity are not required for endotoxin protection from hyperoxia and suggests that TNF and IL-1 may participate in the mechanism of endotoxin protection.


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[Abstract] [Full Text] [PDF]


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