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J Appl Physiol 68: 478-483, 1990;
8750-7587/90 $5.00
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Journal of Applied Physiology, Vol 68, Issue 2 478-483, Copyright © 1990 by American Physiological Society

ARTICLES

Effect of superior vena caval hypertension on alloxan-induced lung injury in dogs

F. Ando, M. Arakawa, K. Kambara, H. Miyazaki, T. Segawa and S. Hirakawa
Second Department of Internal Medicine, School of Medicine, Gifu University, Japan.

To investigate how fast and to what extent superior vena caval hypertension (SVCH) increases lung water in acute increased-permeability state, we studied the time course of lung water accumulation for 3 h in anesthetized dogs under different treatments: 1) controls without intervention (5 dogs), 2) SVCH alone (5 dogs), 3) mild lung microvascular injury induced by low-dose alloxan (75 mg/kg) alone (5 dogs), and 4) SVCH coupled with low-dose alloxan (5 dogs). Neither low-dose alloxan alone nor SVCH alone [superior vena caval pressure (Psvc) = 11.0 +/- 3.1 (SD) mmHg] increased lung water significantly. The SVCH coupled with low-dose alloxan (Psvc = 11.3 +/- 2.7 mmHg) doubled extravascular lung thermal volume measured by the thermal-dye dilution technique within 1 h (5.3 +/- 0.9 ml/kg at base line and 10.9 +/- 4.7 ml/kg at 1 h), then remained unchanged (12.5 +/- 5.7 ml/kg at 3 h). This increase in lung water was confirmed by gravimetric method (5.69 +/- 1.71 g/g blood-free dry wt). We conclude that SVCH is one of the factors that may promote lung water accumulation in increased-permeability state.


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J. W. Klaesner, N. A. Pou, R. E. Parker, C. Finney, and R. J. Roselli
Optical measurement of isolated canine lung filtration coefficients after alloxan infusion
J Appl Physiol, April 1, 1998; 84(4): 1381 - 1387.
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