Journal of Applied Physiology, Vol 67, Issue 6 2565-2570, Copyright © 1989 by American Physiological Society
Effect of exercise, hyperpnea, and bronchoconstriction on plasma atrial natriuretic peptide
I. Rubinstein, T. F. Reiss, D. G. Gardner, J. Liu, B. G. Bigby and H. A. Boushey Jr
Cardiovascular Research Institute, University of California, San Francisco 94143-0130.
To examine whether endogenous secretion of atrial natriuretic peptide (ANP)
modifies the bronchomotor response to moderately strenuous exercise and,
conversely, whether hyperpnea of exercise or bronchoconstriction alone
modulates the release of ANP, we compared the rise in specific airway
resistance and the rise in circulating immunoreactive ANP (IR-ANP) induced
by a 5-min submaximal exercise and by eucapnic hyperpnea with cold dry air
and exercise-matched minute ventilation in six healthy individuals and in
five subjects with clinically stable asthma. As expected, the increase in
specific airway resistance from base line provoked by exercise was greater
in the asthmatic subjects (from 11.8 +/- 7.1 to 34.0 +/- 18.6
l.cmH2O.l-1.s-1) than in the healthy subjects (from 3.7 +/- 1.2 to 4.5 +/-
1.9 l.cmH2O.l-1.s-1). In both groups, exercise was associated with a
similar and significant rise in plasma IR-ANP levels, ranging from 222 to
550% from base-line value in the healthy group and from 176 to 1,120% from
base-line value in the asthmatic group. Peak plasma IR-ANP levels occurred
from 3 to 15 min after completion of exercise with a return to base-line
values within 60 min. Although eucapnic hyperpnea was associated with a
similar increase in specific airway resistance as was exercise, it provoked
an increase in circulating IR-ANP in only one subject.(ABSTRACT TRUNCATED
AT 250 WORDS)
