| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 67, Issue 6 2219-2229, Copyright © 1989 by American Physiological Society
ARTICLES |
T. Similowski, P. Levy, C. Corbeil, M. Albala, R. Pariente, J. P. Derenne, J. H. Bates, B. Jonson and J. Milic-Emili
Institut National de la Sante et de la Recherche Medicale U226, Faculte Bichat, Paris, France.
Pulmonary and chest wall mechanics were studied in six anesthetized paralyzed dogs, by use of the technique of rapid airway occlusion during constant flow inflation. Analysis of the pressure changes after flow interruption allowed us to partition the overall resistance of the lung (Rl) and chest wall (Rw) and total respiratory system (Rrs) into two components, one (Rinit) reflecting in the lung airway resistance (Raw), the other (delta R) reflecting primarily the viscoelastic properties of the pulmonary and chest wall tissues. The effects of varying inspiratory flow and inflation volume were interpreted in terms of frequency dependence of resistance, by using a spring-and-dashpot model previously proposed and substantiated by Bates et al. (Proc. 9th Annu. Conf. IEEE Med. Biol. Soc., 1987, vol. 3, p. 1802-1803). We observed that 1) Raw and Rw,init were nearly equal and small relative to Rl and Rw (both were unaffected by flow); 2) Rrs,init decreased slightly with increasing volume; 3) both delta Rl and delta Rw decreased with increasing flow and increased with increasing lung volume. These changes were manifestations of frequency dependence of delta R, as it is predicted by the model; 4) Rrs, Rl, and Rw followed the same trends as delta R. These results corroborate data previously reported in the literature with the use of different techniques to measure airways and pulmonary tissue resistances and confirm that the use of Rl to assess bronchial reactivity is problematic. The interrupter techniques provides a convenient way to obtain Raw values, as well as analogs of lung and chest wall tissue resistances in intact dogs.
This article has been cited by other articles:
|
|
 |
|
  R. S. Syring, C. M. Otto, R. E. Spivack, K. Markstaller, and J. E. Baumgardner Maintenance of end-expiratory recruitment with increased respiratory rate after saline-lavage lung injury J Appl Physiol, January 1, 2007; 102(1): 331 - 339. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Farias, D. S. Faffe, D. G. Xisto, M. C. E. Santana, R. Lassance, L. F. M. Prota, M. B. Amato, M. M. Morales, W. A. Zin, and P. R. M. Rocco Positive end-expiratory pressure prevents lung mechanical stress caused by recruitment/derecruitment J Appl Physiol, January 1, 2005; 98(1): 53 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Dias, C. P. Passaro, V. R. Cagido, M. Einicker-Lamas, J. Lowe, E. M. Negri, V. L. Capelozzi, W. A. Zin, and P. R. M. Rocco Effects of undernutrition on respiratory mechanics and lung parenchyma remodeling J Appl Physiol, November 1, 2004; 97(5): 1888 - 1896. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Perchiazzi, R. Giuliani, L. Ruggiero, T. Fiore, and G. Hedenstierna Estimating Respiratory System Compliance During Mechanical Ventilation Using Artificial Neural Networks Anesth. Analg., October 1, 2003; 97(4): 1143 - 1148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.R.M. Rocco, D.P. Momesso, R.C. Figueira, H.C. Ferreira, R.A. Cadete, A. Legora-Machado, V.L.G. Koatz, L.M. Lima, E.J. Barreiro, and W.A. Zin Therapeutic potential of a new phosphodiesterase inhibitor in acute lung injury Eur. Respir. J., July 1, 2003; 22(1): 20 - 27. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Conti, G. De Cosmo, M. G. Bocci, M. Antonelli, G. Ferro, R. Costa, G. Zito, and R. Proietti Alfentanil does not increase resistance of the respiratory system in ASA I patients ventilated mechanically during general anesthesia: [L'alfentanil n'augmente pas la resistance du systeme respiratoire chez des patients d'etat physique ASA I ventiles mecaniquement pendant l'anesthesie generale] Can J Anesth, August 1, 2002; 49(7): 718 - 723. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Guerin, G. Fournier, and J. Milic-Emili Effects of PEEP on inspiratory resistance in mechanically ventilated COPD patients Eur. Respir. J., September 1, 2001; 18(3): 491 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. C. F. Correa, P. B. Ciminelli, H. Falcao, B. J. C. Alcantara, R. S. Contador, A. S. Medeiros, W. A. Zin, and P. R. M. Rocco Respiratory mechanics and lung histology in normal rats anesthetized with sevoflurane J Appl Physiol, August 1, 2001; 91(2): 803 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. De Robertis, J.M. Liu, S. Blomquist, P.L. Dahm, J. Thorne, and B. Jonson Elastic properties of the lung and the chest wall in young and adult healthy pigs Eur. Respir. J., April 1, 2001; 17(4): 703 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. NÈVE, E. D. de la ROQUE, F. LECLERC, S. LETEURTRE, A. DORKENOO, A. SADIK, R. CREMER, and R. LOGIER Ventilator-induced Overdistension in Children . Dynamic versus Low-flow Inflation Volume-Pressure Curves Am. J. Respir. Crit. Care Med., July 1, 2000; 162(1): 139 - 147. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. L.S. Menezes, P. S.C. Chagas, A. V. Macedo-Neto, V. C.T. Santos, P. R.M. Rocco, and W. A. Zin Suture or Prosthetic Reconstruction of Experimental Diaphragmatic Defects Chest, May 1, 2000; 117(5): 1443 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. KADITIS, S. T. VENKATARAMAN, W. A. ZIN, and E. K. MOTOYAMA Partitioning of Respiratory System Resistance in Children with Respiratory Insufficiency Am. J. Respir. Crit. Care Med., February 1, 1999; 159(2): 389 - 396. [Abstract] [Full Text]
|
|
|
|
 |
|
 B. Jonson and C. Svantesson Elastic pressure-volume curves: what information do they convey? Thorax, January 1, 1999; 54(1): 82 - 87. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
