Journal of Applied Physiology http://www.adinstruments.com/labchart/faseb
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 67: 2095-2100, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Somers, V. K.
Right arrow Articles by Abboud, F. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Somers, V. K.
Right arrow Articles by Abboud, F. M.

Journal of Applied Physiology, Vol 67, Issue 5 2095-2100, Copyright © 1989 by American Physiological Society

ARTICLES

Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans

V. K. Somers, A. L. Mark, D. C. Zavala and F. M. Abboud
Department of Medicine, University of Iowa, Iowa City 55242.

The sympathetic response to hypoxia depends on the interaction between chemoreceptor stimulation (CRS) and the associated hyperventilation. We studied this interaction by measuring sympathetic nerve activity (SNA) to muscle in 13 normal subjects, while breathing room air, 14% O2, 10% O2, and 10% O2 with added CO2 to maintain isocapnia. Minute ventilation (VE) and blood pressure (BP) increased significantly more during isocapnic hypoxia (IHO) than hypocapnic hypoxia (HHO). In contrast, SNA increased more during HHO [40 +/- 10% (SE)] than during IHO (25 +/- 19%, P less than 0.05). To determine the reason for the lesser increase in SNA with IHO, 11 subjects underwent voluntary apnea during HHO and IHO. Apnea potentiated the SNA responses to IHO more than to HHO. SNA responses to IHO were 17 +/- 7% during breathing and 173 +/- 47% during apnea whereas SNA responses to HHO were 35 +/- 8% during breathing and 126 +/- 28% during apnea. During ventilation, the sympathoexcitation of IHO (compared with HHO) is suppressed, possibly for two reasons: 1) because of the inhibitory influence of activation of pulmonary afferents as a result of a greater increase in VE, and 2) because of the inhibitory influence of baroreceptor activation due to a greater rise in BP. Thus in humans, the ventilatory response to chemoreceptor stimulation predominates and restrains the sympathetic response. The SNA response to chemoreceptor stimulation represents the net effect of the excitatory influence of the chemoreflex and the inhibitory influence of pulmonary afferents and baroreceptor afferents.


This article has been cited by other articles:


Home page
 CirculationHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
Circulation, September 2, 2008; 118(10): 1080 - 1111.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
V. K. Somers, D. P. White, R. Amin, W. T. Abraham, F. Costa, A. Culebras, S. Daniels, J. S. Floras, C. E. Hunt, L. J. Olson, et al.
Sleep Apnea and Cardiovascular Disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement From the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing In Collaboration With the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health)
J. Am. Coll. Cardiol., August 19, 2008; 52(8): 686 - 717.
[Full Text] [PDF]

Home page
 ChestHome page
F. Lopez-Jimenez, F. H. Sert Kuniyoshi, A. Gami, and V. K. Somers
Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease
Chest, March 1, 2008; 133(3): 793 - 804.
[Full Text] [PDF]

Home page
 J. Physiol.Home page
B. W. Wilkins, T. L. Pike, E. A. Martin, T. B. Curry, M. L. Ceridon, and M. J. Joyner
Exercise intensity-dependent contribution of {beta}-adrenergic receptor-mediated vasodilatation in hypoxic humans
J. Physiol., February 15, 2008; 586(4): 1195 - 1205.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Gujic, C. Dreyfuss, J.-F. Argacha, S. Beloka, D. Adamopoulos, O. Xhaet, A. Pathak, and P. van de Borne
Effects of enoximone on peripheral and central chemoreflex responses in humans
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H322 - H329.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Gujic, D. Laude, A. Houssiere, S. Beloka, J.-F. Argacha, D. Adamopoulos, O. Xhaet, J.-L. Elghozi, and P. van de Borne
Differential effects of metaboreceptor and chemoreceptor activation on sympathetic and cardiac baroreflex control following exercise in hypoxia in human
J. Physiol., November 15, 2007; 585(1): 165 - 174.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Tamisier, B. E. Hunt, G. S. Gilmartin, M. Curley, A. Anand, and J. W. Weiss
Hemodynamics and muscle sympathetic nerve activity after 8 h of sustained hypoxia in healthy humans
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3027 - H3035.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Johnson, S. Hudson, and J. Marshall
Responses evoked in single sympathetic nerve fibres of the rat tail artery by systemic hypoxia are dependent on core temperature
J. Physiol., October 1, 2007; 584(1): 221 - 233.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. H. Simmons, J. M. Manson, and J. R. Halliwill
Mild central chemoreflex activation does not alter arterial baroreflex function in healthy humans
J. Physiol., September 15, 2007; 583(3): 1155 - 1163.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Di Vanna, A. M. F. W. Braga, M. C. Laterza, L. M. Ueno, M. U. P. B. Rondon, A. C. P. Barretto, H. R. Middlekauff, and C. E. Negrao
Blunted muscle vasodilatation during chemoreceptor stimulation in patients with heart failure
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H846 - H852.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. D. Schultz, Y. L. Li, and Y. Ding
Arterial Chemoreceptors and Sympathetic Nerve Activity: Implications for Hypertension and Heart Failure
Hypertension, July 1, 2007; 50(1): 6 - 13.
[Full Text] [PDF]

Home page
 ChestHome page
V. A. Imadojemu, Z. Mawji, A. Kunselman, K. S. Gray, C. S. Hogeman, and U. A. Leuenberger
Sympathetic Chemoreflex Responses in Obstructive Sleep Apnea and Effects of Continuous Positive Airway Pressure Therapy
Chest, May 1, 2007; 131(5): 1406 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Y.-H. Du and A. F. Chen
A "love triangle" elicited by electrochemistry: complex interactions among cardiac sympathetic afferent, chemo-, and baroreflexes
J Appl Physiol, January 1, 2007; 102(1): 9 - 10.
[Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. Mahamed and G. S. Mitchell
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?
Exp Physiol, January 1, 2007; 92(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
M. L. Smith and C. F. Pacchia
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Sleep apnoea and hypertension: role of chemoreflexes in humans
Exp Physiol, January 1, 2007; 92(1): 45 - 50.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. W. Wilkins, W. G. Schrage, Z. Liu, K. C. Hancock, and M. J. Joyner
Systemic hypoxia and vasoconstrictor responsiveness in exercising human muscle
J Appl Physiol, November 1, 2006; 101(5): 1343 - 1350.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
K. Usui, J. D. Parker, G. E. Newton, J. S. Floras, C. M. Ryan, and T. D. Bradley
Left Ventricular Structural Adaptations to Obstructive Sleep Apnea in Dilated Cardiomyopathy
Am. J. Respir. Crit. Care Med., May 15, 2006; 173(10): 1170 - 1175.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Narkiewicz, P. van de Borne, N. Montano, D. Hering, T. Kara, and V. K. Somers
Sympathetic Neural Outflow and Chemoreflex Sensitivity Are Related to Spontaneous Breathing Rate in Normal Men
Hypertension, January 1, 2006; 47(1): 51 - 55.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
N. Iiyori, M. Shirahata, and C. P. O'Donnell
Genetic background affects cardiovascular responses to obstructive and simulated apnea
Physiol Genomics, December 14, 2005; 24(1): 65 - 72.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. M. Punjabi and V. Y. Polotsky
Disorders of glucose metabolism in sleep apnea
J Appl Physiol, November 1, 2005; 99(5): 1998 - 2007.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Andreas, S. D. Anker, P. D. Scanlon, and V. K. Somers
Neurohumoral Activation as a Link to Systemic Manifestations of Chronic Lung Disease
Chest, November 1, 2005; 128(5): 3618 - 3624.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
K. Gugleta, S. Orgul, P. Hasler, and J. Flammer
Circulatory Response to Blood Gas Perturbations in Vasospasm
Invest. Ophthalmol. Vis. Sci., September 1, 2005; 46(9): 3288 - 3294.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. J. Cutler, N. M. Swift, D. M. Keller, W. L. Wasmund, J. R. Burk, and M. L. Smith
Periods of intermittent hypoxic apnea can alter chemoreflex control of sympathetic nerve activity in humans
Am J Physiol Heart Circ Physiol, November 1, 2004; 287(5): H2054 - H2060.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Muenter Swift, M. J. Cutler, P. J. Fadel, W. L. Wasmund, S. Ogoh, D. M. Keller, P. B. Raven, and M. L. Smith
Carotid baroreflex function during and following voluntary apnea in humans
Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2411 - H2419.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. P. Blaber, T. Hartley, and P. J. Pretorius
Effect of acute exposure to 3,660 m altitude on orthostatic responses and tolerance
J Appl Physiol, August 1, 2003; 95(2): 591 - 601.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
R. Kanagala, N. S. Murali, P. A. Friedman, N. M. Ammash, B. J. Gersh, K. V. Ballman, A. S. M. Shamsuzzaman, and V. K. Somers
Obstructive Sleep Apnea and the Recurrence of Atrial Fibrillation
Circulation, May 27, 2003; 107(20): 2589 - 2594.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Andreas, C. Bingeli, P. Mohacsi, T. F. Luscher, and G. Noll
Nasal Oxygen and Muscle Sympathetic Nerve Activity in Heart Failure
Chest, February 1, 2003; 123(2): 366 - 371.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
L. Bernardi, M. Hilz, B. Stemper, C. Passino, G. Welsch, and F. B. Axelrod
Respiratory and Cerebrovascular Responses to Hypoxia and Hypercapnia in Familial Dysautonomia
Am. J. Respir. Crit. Care Med., January 15, 2003; 167(2): 141 - 149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
C. P. O'Donnell, L. Allan, P. Atkinson, and A. R. Schwartz
The Effect of Upper Airway Obstruction and Arousal on Peripheral Arterial Tonometry in Obstructive Sleep Apnea
Am. J. Respir. Crit. Care Med., October 1, 2002; 166(7): 965 - 971.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
J. R. Halliwill and C. T. Minson
Effect of hypoxia on arterial baroreflex control of heart rate and muscle sympathetic nerve activity in humans
J Appl Physiol, September 1, 2002; 93(3): 857 - 864.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
J. A. Soares Barreto-Filho, F. M. Consolim-Colombo, H. Ferreira Lopes, C. R. Martins Sobrinho, G. M. Guerra-Riccio, and E. M. Krieger
Dysregulation of Peripheral and Central Chemoreflex Responses in Chagas' Heart Disease Patients Without Heart Failure
Circulation, October 9, 2001; 104(15): 1792 - 1798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. K. Shoemaker, D. D. O'Leary, and R. L. Hughson
PETCO2 inversely affects MSNA response to orthostatic stress
Am J Physiol Heart Circ Physiol, September 1, 2001; 281(3): H1040 - H1046.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Van De Borne, N. Montano, K. Narkiewicz, J. P. Degaute, A. Malliani, M. Pagani, and V. K. Somers
Importance of ventilation in modulating interaction between sympathetic drive and cardiovascular variability
Am J Physiol Heart Circ Physiol, February 1, 2001; 280(2): H722 - H729.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Xie, J. B. Skatrud, D. C. Crabtree, D. S. Puleo, B. M. Goodman, and B. J. Morgan
Neurocirculatory consequences of intermittent asphyxia in humans
J Appl Physiol, October 1, 2000; 89(4): 1333 - 1339.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Van de Borne, S. Mezzetti, N. Montano, K. Narkiewicz, J. P. Degaute, and V. K. Somers
Hyperventilation alters arterial baroreflex control of heart rate and muscle sympathetic nerve activity
Am J Physiol Heart Circ Physiol, August 1, 2000; 279(2): H536 - H541.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. C. Fletcher, G. Bao, and R. Li
Renin Activity and Blood Pressure in Response to Chronic Episodic Hypoxia
Hypertension, August 1, 1999; 34(2): 309 - 314.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Narkiewicz, C. A. Pesek, P. J. H. van de Borne, M. Kato, and V. K. Somers
Enhanced Sympathetic and Ventilatory Responses to Central Chemoreflex Activation in Heart Failure
Circulation, July 20, 1999; 100(3): 262 - 267.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. Narkiewicz, M. Kato, C. A. Pesek, and V. K. Somers
Human Obesity Is Characterized by a Selective Potentiation of Central Chemoreflex Sensitivity
Hypertension, May 1, 1999; 33(5): 1153 - 1158.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Duplain, L. Vollenweider, A. Delabays, P. Nicod, P. Bartsch, and U. Scherrer
Augmented Sympathetic Activation During Short-Term Hypoxia and High-Altitude Exposure in Subjects Susceptible to High-Altitude Pulmonary Edema
Circulation, April 6, 1999; 99(13): 1713 - 1718.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S.-Y. Sun, W. Wang, I. H. Zucker, and H. D. Schultz
Enhanced peripheral chemoreflex function in conscious rabbits with pacing-induced heart failure
J Appl Physiol, April 1, 1999; 86(4): 1264 - 1272.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Narkiewicz, P. J. H. van de Borne, C. A. Pesek, M. E. Dyken, N. Montano, and V. K. Somers
Selective Potentiation of Peripheral Chemoreflex Sensitivity in Obstructive Sleep Apnea
Circulation, March 9, 1999; 99(9): 1183 - 1189.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Narkiewicz, P. J. H. van de Borne, R. L. Cooley, M. E. Dyken, and V. K. Somers
Sympathetic Activity in Obese Subjects With and Without Obstructive Sleep Apnea
Circulation, August 25, 1998; 98(8): 772 - 776.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. van de Borne, R. Oren, and V. K. Somers
Dopamine Depresses Minute Ventilation in Patients With Heart Failure
Circulation, July 14, 1998; 98(2): 126 - 131.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. E. Bharucha, V. Novak, M. Camilleri, A. R. Zinsmeister, R. B. Hanson, and P. A. Low
alpha 2-Adrenergic modulation of colonic tone during hyperventilation
Am J Physiol Gastrointest Liver Physiol, November 1, 1997; 273(5): G1135 - G1140.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. Chen and S. M. Scharf
Comparative hemodynamic effects of periodic obstructive and simulated central apneas in sedated pigs
J Appl Physiol, August 1, 1997; 83(2): 485 - 494.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. Bao, N. Metreveli, R. Li, A. Taylor, and E. C. Fletcher
Blood pressure response to chronic episodic hypoxia: role of the sympathetic nervous system
J Appl Physiol, July 1, 1997; 83(1): 95 - 101.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. van de Borne, A. L. Mark, N. Montano, D. Mion, and V. K. Somers
Effects of Alcohol on Sympathetic Activity, Hemodynamics, and Chemoreflex Sensitivity
Hypertension, June 1, 1997; 29(6): 1278 - 1283.
[Abstract] [Full Text]

Home page
 CirculationHome page
P. van de Borne, R. Oren, E. A. Anderson, A. L. Mark, and V. K. Somers
Tonic Chemoreflex Activation Does Not Contribute to Elevated Muscle Sympathetic Nerve Activity in Heart Failure
Circulation, September 15, 1996; 94(6): 1325 - 1328.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online