| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 67, Issue 5 1898-1902, Copyright © 1989 by American Physiological Society
ARTICLES |
R. G. Presson Jr, K. R. Kirk, K. A. Haselby, J. H. Linehan, S. Zaleski and W. W. Wagner Jr
Department of Anesthesia, Indiana University School of Medicine, Indianapolis 46202.
The lung serves an important nonrespiratory function by trapping and excreting venous air emboli. The site of trapping and the mechanism of excretion, however, are uncertain. To observe the behavior of bubbles in the pulmonary circulation, we injected venous air emboli into anesthetized dogs and videotaped their elimination from the pulmonary microcirculation by using in vivo microscopy. Small intravenous bubbles lodged exclusively in pulmonary arterioles and were eliminated from that site. To determine whether the gas was dissolving into nearby blood and then was carried to the capillaries for excretion, the rate of bubble radius change was measured during nonperfused conditions produced by balloon occlusion of lobar blood flow and compared with perfused conditions. Bubble volume decreased at the same rate during perfused and nonperfused conditions and thus was independent of regional blood flow. Molecular diffusion of gas directly across the arteriolar wall into alveolar spaces was the most likely mechanism of elimination because calculations based on the Fick equation for molecular diffusion predict an elimination rate nearly identical with those observed experimentally.
This article has been cited by other articles:
|
|
 |
|
  A. J. Calderon, J. B. Fowlkes, and J. L. Bull Bubble splitting in bifurcating tubes: a model study of cardiovascular gas emboli transport J Appl Physiol, August 1, 2005; 99(2): 479 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. J. E. Lamm, S. L. Bernard, W. W. Wagner Jr., and R. W. Glenny Intravital microscopic observations of 15-{micro}m microspheres lodging in the pulmonary microcirculation J Appl Physiol, June 1, 2005; 98(6): 2242 - 2248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Frasco, R. E. Caswell, and D. Novicki Venous Air Embolism During Transurethral Resection of the Prostate Anesth. Analg., December 1, 2004; 99(6): 1864 - 1866. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Droghetti, M. Giganti, A. Memmo, and R. Zatelli Air embolism: diagnosis with single-photon emission tomography and successful hyperbaric oxygen therapy Br. J. Anaesth., November 1, 2002; 89(5): 775 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Haller, E. Faltin-Traub, D. Faltin, and C. Kern Oxygen embolism after hydrogen peroxide irrigation of a vulvar abscess Br. J. Anaesth., April 1, 2002; 88(4): 597 - 599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Chen and Y. R. Kou Vagal and mediator mechanisms underlying the tachypnea caused by pulmonary air embolism in dogs J Appl Physiol, April 1, 2000; 88(4): 1247 - 1253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Souders, J. B. Doshier, N. L. Polissar, and M. P. Hlastala Spatial distribution of venous gas emboli in the lungs J Appl Physiol, November 1, 1999; 87(5): 1937 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Tanus-Santos, H. Moreno Jr., A. Zappellini, and G. de Nucci Small-Dose Inhaled Nitric Oxide Attenuates Hemodynamic Changes After Pulmonary Air Embolism in Dogs Anesth. Analg., May 1, 1999; 88(5): 1025 - 1029. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. F. Chen, B. P. Lee, and Y. R. Kou Mechanisms of stimulation of vagal pulmonary C fibers by pulmonary air embolism in dogs J Appl Physiol, March 1, 1997; 82(3): 765 - 771. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kurusz, B. D Butler, J. Katz, and V. R Conti Air embolism during cardiopulmonary bypass Perfusion, November 1, 1995; 10(6): 361 - 391. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
