| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 67, Issue 5 1827-1834, Copyright © 1989 by American Physiological Society
ARTICLES |
K. C. Darr and E. Schultz
Biodynamics Laboratory, University of Wisconsin, Madison 53706.
The effects of long-term hindlimb unweighting by tail suspension on postnatal growth of 20-day rat extensor digitorum longus (EDL) and soleus muscles were studied. Morphological assay indicated that radial growth of soleus myofibers was completely inhibited between 3 and 10 days of suspension and reduced thereafter, leading to a severe attenuation (-76% from control) over the total experimental period. Longitudinal growth rate, however, was accelerated 40% over weight-bearing controls. In addition, myofibers were arranged parallel to the long axis of the muscle, an orientation associated with chronologically younger muscles, suggesting morphological maturation of the soleus muscle had been delayed by suspension. In contrast, radial and longitudinal growth of EDL myofibers were minimally affected under similar conditions and remained within approximately 5% of control at all times. Suspension also influenced the normal changes that occur in satellite cell and myonuclear populations during postnatal growth. Both the number and proliferative activity of satellite cells were severely reduced in individual myofibers after only 3 days in both soleus and EDL muscles. The reduced number of satellite cells within 3 days of initiating hindlimb suspension appeared to be the result of their incorporation into myofibers while the long-lasting reduction appeared to be the added effects of decreased proliferative activity. In the soleus, this reduction in number and proliferation of satellite cells persisted throughout the experimental period and resulted in an overall 43% fewer myonuclei and 45% fewer satellite cells than control at 50 days of age. In contrast, both the total number and mitotic activity of satellite cells in the EDL rapidly returned to weight-bearing control levels by day 10 of suspension, resulting in no overall reduction in myonuclear accretion.
This article has been cited by other articles:
|
|
 |
|
  K. Gundersen and J. C. Bruusgaard Nuclear domains during muscle atrophy: nuclei lost or paradigm lost? J. Physiol., June 1, 2008; 586(11): 2675 - 2681. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Zhan, B. Jin, S.-E. Chen, J. M. Reecy, and Y.-P. Li TACE release of TNF-{alpha} mediates mechanotransduction-induced activation of p38 MAPK and myogenesis J. Cell Sci., February 15, 2007; 120(4): 692 - 701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Koncarevic, R. W. Jackman, and S. C. Kandarian The ubiquitin-protein ligase Nedd4 targets Notch1 in skeletal muscle and distinguishes the subset of atrophies caused by reduced muscle tension FASEB J, February 1, 2007; 21(2): 427 - 437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fornaro, P. M. Burch, W. Yang, L. Zhang, C. E. Hamilton, J. H. Kim, B. G. Neel, and A. M. Bennett SHP-2 activates signaling of the nuclear factor of activated T cells to promote skeletal muscle growth J. Cell Biol., October 9, 2006; 175(1): 87 - 97. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. McClung, J. M. Davis, M. A. Wilson, E. C. Goldsmith, and J. A. Carson Estrogen status and skeletal muscle recovery from disuse atrophy J Appl Physiol, June 1, 2006; 100(6): 2012 - 2023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. D. Wang, F. Kawano, Y. Matsuoka, K. Fukunaga, M. Terada, M. Sudoh, A. Ishihara, and Y. Ohira Mechanical load-dependent regulation of satellite cell and fiber size in rat soleus muscle Am J Physiol Cell Physiol, April 1, 2006; 290(4): C981 - C989. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I.-H. Park and J. Chen Mammalian Target of Rapamycin (mTOR) Signaling Is Required for a Late-stage Fusion Process during Skeletal Myotube Maturation J. Biol. Chem., September 9, 2005; 280(36): 32009 - 32017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fluck, S. Schmutz, M. Wittwer, H. Hoppeler, and D. Desplanches Transcriptional reprogramming during reloading of atrophied rat soleus muscle Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R4 - R14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Mitchell and G. K. Pavlath Skeletal muscle atrophy leads to loss and dysfunction of muscle precursor cells Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1753 - C1762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Washington, J. M. Reecy, R. W. Thompson, L. L. Lowe, J. M. McClung, and J. A. Carson Lactate dehydrogenase expression at the onset of altered loading in rat soleus muscle J Appl Physiol, October 1, 2004; 97(4): 1424 - 1430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Gallegly, N. A. Turesky, B. A. Strotman, C. M. Gurley, C. A. Peterson, and E. E. Dupont-Versteegden Satellite cell regulation of muscle mass is altered at old age J Appl Physiol, September 1, 2004; 97(3): 1082 - 1090. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sajko, L. Kubinova, E. Cvetko, M. Kreft, A. Wernig, and I. Erzen Frequency of M-Cadherin-stained Satellite Cells Declines in Human Muscles During Aging J. Histochem. Cytochem., February 1, 2004; 52(2): 179 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. McMahon, L. Popovic, J. M. Oldham, F. Jeanplong, H. K. Smith, R. Kambadur, M. Sharma, L. Maxwell, and J. J. Bass Myostatin-deficient mice lose more skeletal muscle mass than wild-type controls during hindlimb suspension Am J Physiol Endocrinol Metab, July 1, 2003; 285(1): E82 - E87. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Horsley and G. K. Pavlath Prostaglandin F2{alpha} stimulates growth of skeletal muscle cells via an NFATC2-dependent pathway J. Cell Biol., April 14, 2003; 161(1): 111 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-M. Chen, N. S. Stott, and H. K. Smith Effects of botulinum toxin A injection and exercise on the growth of juvenile rat gastrocnemius muscle J Appl Physiol, October 1, 2002; 93(4): 1437 - 1447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. O. Mitchell and G. K. Pavlath A muscle precursor cell-dependent pathway contributes to muscle growth after atrophy Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1706 - C1715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Hawke and D. J. Garry Myogenic satellite cells: physiology to molecular biology J Appl Physiol, August 1, 2001; 91(2): 534 - 551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. E. Mozdziak, P. M. Pulvermacher, and E. Schultz Muscle regeneration during hindlimb unloading results in a reduction in muscle size after reloading J Appl Physiol, July 1, 2001; 91(1): 183 - 190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Horsley, B. B. Friday, S. Matteson, K. M. Kegley, J. Gephart, and G. K. Pavlath Regulation of the Growth of Multinucleated Muscle Cells by an NFATC2-dependent Pathway J. Cell Biol., April 16, 2001; 153(2): 329 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Ohira, T. Tanaka, T. Yoshinaga, F. Kawano, T. Nomura, I. Nonaka, D. L. Allen, R. R. Roy, and V. R. Edgerton Ontogenetic, gravity-dependent development of rat soleus muscle Am J Physiol Cell Physiol, April 1, 2001; 280(4): C1008 - C1016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Seward, J. C. Haney, M. A. Rudnicki, and S. J. Swoap bHLH transcription factor MyoD affects myosin heavy chain expression pattern in a muscle-specific fashion Am J Physiol Cell Physiol, February 1, 2001; 280(2): C408 - C413. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Lambertz, C. Perot, R. Kaspranski, and F. Goubel Effects of long-term spaceflight on mechanical properties of muscles in humans J Appl Physiol, January 1, 2001; 90(1): 179 - 188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Dupont-Versteegden, R. J. L. Murphy, J. D. Houle, C. M. Gurley, and C. A. Peterson Mechanisms leading to restoration of muscle size with exercise and transplantation after spinal cord injury Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1677 - C1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Chakravarthy, B. S. Davis, and F. W. Booth IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle J Appl Physiol, October 1, 2000; 89(4): 1365 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Hikida, R. S. Staron, F. C. Hagerman, S. Walsh, E. Kaiser, S. Shell, and S. Hervey Effects of High-Intensity Resistance Training on Untrained Older Men. II. Muscle Fiber Characteristics and Nucleo-Cytoplasmic Relationships J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2000; 55(7): 347B - 354. [Abstract] [Full Text]
|
|
|
|
|
|
P. E. Mozdziak, P. M. Pulvermacher, and E. Schultz Unloading of juvenile muscle results in a reduced muscle size 9 wk after reloading J Appl Physiol, January 1, 2000; 88(1): 158 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. WEHLING, B. CAI, and J. G. TIDBALL Modulation of myostatin expression during modified muscle use FASEB J, January 1, 2000; 14(1): 103 - 110. [Abstract] [Full Text]
|
|
|
|
|
|
E. E. Dupont-Versteegden, R. J. L. Murphy, J. D. Houle, C. M. Gurley, and C. A. Peterson Activated satellite cells fail to restore myonuclear number in spinal cord transected and exercised rats Am J Physiol Cell Physiol, September 1, 1999; 277(3): C589 - C597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Roy, S. R. Monke, D. L. Allen, and V. R. Edgerton Modulation of myonuclear number in functionally overloaded and exercised rat plantaris fibers J Appl Physiol, August 1, 1999; 87(2): 634 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Carlson, F. W. Booth, and S. E. Gordon Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1999; 277(2): R601 - R606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Wheeler, E. C. Snyder, M. N. Patterson, and S. J. Swoap An E-box within the MHC IIB gene is bound by MyoD and is required for gene expression in fast muscle Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1069 - C1078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Putman, S. Dusterhoft, and D. Pette Changes in satellite cell content and myosin isoforms in low-frequency-stimulated fast muscle of hypothyroid rat J Appl Physiol, January 1, 1999; 86(1): 40 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Dupont-Versteegden, J. D. Houle, C. M. Gurley, and C. A. Peterson Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise Am J Physiol Cell Physiol, October 1, 1998; 275(4): C1124 - C1133. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
