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J Appl Physiol 67: 1623-1629, 1989;
8750-7587/89 $5.00
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Journal of Applied Physiology, Vol 67, Issue 4 1623-1629, Copyright © 1989 by American Physiological Society

ARTICLES

Lung impedance in healthy humans measured by forced oscillations from 0.01 to 0.1 Hz

B. Suki, R. Peslin, C. Duvivier and R. Farre
Unite 14 Institut National de la Sante et de la Recherche Medicale, Physiopathologie Respiratoire, Vandoeuvre-les-Nancy, France.

Lung impedance was measured from 0.01 to 0.1 Hz in six healthy adults by superimposing small-amplitude forced oscillations on spontaneous breathing. Measurements were made with an almost constant-volume input (160-180 ml) or with an almost constant-flow input (20-30 ml.s-1). No significant difference was found between the two conditions. Lung resistance (RL) sharply decreased from 0.97 kPa.l-1.s at 0.01 Hz to 0.27 kPa.l-1.s at 0.03 Hz and then mildly to 0.23 kPa.l-1.s at 0.1 Hz. Lung effective compliance (CL) decreased slightly and regularly from 0.01 Hz (2.38 l.kPa-1) to 0.1 Hz (1.93 l.kPa-1). The data were analyzed using a linear viscoelastic model adapted from Hildebrandt (J. Appl. Physiol. 28:365-372, 1970) and complemented by a Newtonian resistance (R): RL = R + B/(9.2f); CL = 1/(A + 0.25B + B.log2 pi f), where f is the frequency and B/A is an index of lung tissue viscoelasticity. A good fit was generally obtained, with an average difference of 10% between the observed and predicted values. The ratio B/A was not affected by the breathing and was 10.6 and 13.6% in the constant-volume and constant-flow conditions, respectively, which agrees with Hildebrandt's observations in isolated cat lungs. R was systematically larger than the plethysmographic airway resistance, suggesting that lung tissue resistance might also include a Newtonian component.


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D. W. Kaczka, E. P. Ingenito, B. Suki, and K. R. Lutchen
Partitioning airway and lung tissue resistances in humans: effects of bronchoconstriction
J Appl Physiol, May 1, 1997; 82(5): 1531 - 1541.
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