Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 67: 1597-1605, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stevens, P. A.
Right arrow Articles by Clements, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stevens, P. A.
Right arrow Articles by Clements, J. A.

Journal of Applied Physiology, Vol 67, Issue 4 1597-1605, Copyright © 1989 by American Physiological Society

ARTICLES

Surfactant secretion and clearance in the newborn

P. A. Stevens, J. R. Wright and J. A. Clements
Cardiovascular Research Institute, University of California, San Francisco 94143.

Pregnant rabbits (30 days) were injected intravenously with [3H]choline 8 h before delivery. The fetuses were delivered, and lung lavage and lamellar body phospholipids (PL) were analyzed. Some newborns also received radioactively labeled surfactant intratracheally on delivery and were permitted to breathe. With time, intratracheal label decreased in lavage and appeared in the lamellar body fraction, and intravenous label accumulated in both pools. Using a tracer analysis for non-steady state, we calculated surfactant secretion and clearance rates for the newborn period. Before birth, both rates rose slightly from 1.8 micrograms PL.g body wt-1.h-1 at 6 h before birth to 7.3 at birth. Immediately after birth, secretion rate rose to 37.7 micrograms PL.g body wt-1.h-1. Between 1.5 and 2 h after birth it fell to a minimum of 1.8 micrograms PL.g body wt-1.h-1 and then rose slowly to 6.0 at 12 h. After birth, clearance rate increased less than secretion rate (maximum 24.7 micrograms PL.g body wt-1.h-1 shortly after birth) then followed the same pattern but did not balance secretion rate in the 1st day.


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
A. Fehrenbach, C. Bube, J. M. Hohlfeld, P. Stevens, T. Tschernig, H. G. Hoymann, N. Krug, and H. Fehrenbach
Surfactant Homeostasis Is Maintained In Vivo during Keratinocyte Growth Factor-induced Rat Lung Type II Cell Hyperplasia
Am. J. Respir. Crit. Care Med., May 1, 2003; 167(9): 1264 - 1270.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Hawgood, J. Akiyama, C. Brown, L. Allen, G. Li, and F. R. Poulain
GM-CSF mediates alveolar macrophage proliferation and type II cell hypertrophy in SP-D gene-targeted mice
Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1148 - L1156.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Allen, M. Oulton, D. Stinson, J. MacDonald, and A. Allen
Alveolar metabolism of natural vs. synthetic surfactants in preterm newborn rabbits
J Appl Physiol, January 1, 2001; 90(1): 198 - 204.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online