| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Journal of Applied Physiology, Vol 67, Issue 4 1535-1541, Copyright © 1989 by American Physiological Society
ARTICLES |
M. J. Hazucha, D. V. Bates and P. A. Bromberg
Center for Environmental Medicine and Lung Biology, School of Medicine, University of North Carolina, Chapel Hill 27599-7310.
Fourteen healthy normal volunteers were randomly exposed to air and 0.5 ppm of ozone (O3) in a controlled exposure chamber for a 2-h period during which 15 min of treadmill exercise sufficient to produce a ventilation of approximately 40 l/min was alternated with 15-min rest periods. Before testing an esophageal balloon was inserted, and lung volumes, flow rates, maximal inspiratory (at residual volume and functional residual capacity) and expiratory (at total lung capacity and functional residual capacity) mouth pressures, and pulmonary mechanics (static and dynamic compliance and airway resistance) were measured before and immediately after the exposure period. After the postexposure measurements had been completed, the subjects inhaled an aerosol of 20% lidocaine until response to citric acid aerosol inhalation was abolished. All of the measurements were immediately repeated. We found that the O3 exposure 1) induced a significant mean decrement of 17.8% in vital capacity (this change was the result of a marked fall in inspiratory capacity without significant increase in residual volume), 2) significantly increased mean airway resistance and specific airway resistance but did not change dynamic or static pulmonary compliance or viscous or elastic work, 3) significantly reduced maximal transpulmonary pressure (by 19%) but produced no changes in inspiratory or expiratory maximal mouth pressures, and 4) significantly increased respiratory rate (in 5 subjects by more than 6 breaths/min) and decreased tidal volume.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  E. S. Schelegle, W. F. Walby, and W. C. Adams Time course of ozone-induced changes in breathing pattern in healthy exercising humans J Appl Physiol, February 1, 2007; 102(2): 688 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Kjaergaard, O. F. Pedersen, M. R. Miller, T. R. Rasmussen, J. C. Hansen, and L. Molhave Ozone exposure decreases the effect of a deep inhalation on forced expiratory flow in normal subjects J Appl Physiol, May 1, 2004; 96(5): 1651 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Blomberg, I. Mudway, M. Svensson, A. Hagenbjork-Gustafsson, L. Thomasson, R. Helleday, X. Dumont, B. Forsberg, G. Nordberg, and A. Bernard Clara cell protein as a biomarker for ozone-induced lung injury in humans Eur. Respir. J., December 1, 2003; 22(6): 883 - 888. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Hazucha, L. J. Folinsbee, and P. A. Bromberg Distribution and reproducibility of spirometric response to ozone by gender and age J Appl Physiol, November 1, 2003; 95(5): 1917 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. VAGAGGINI, M. TACCOLA, I. CONTI, S. CARNEVALI, S. CIANCHETTI, M. L. BARTOLI, E. BACCI, F. L. DENTE, A. DI FRANCO, D. GIANNINI, et al. Budesonide Reduces Neutrophilic but Not Functional Airway Response to Ozone in Mild Asthmatics Am. J. Respir. Crit. Care Med., December 15, 2001; 164(12): 2172 - 2176. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. FRANK, M. C. LIU, E. W. SPANNHAKE, S. MLYNAREK, K. MACRI, and G. G. WEINMANN Repetitive Ozone Exposure of Young Adults . Evidence of Persistent Small Airway Dysfunction Am. J. Respir. Crit. Care Med., October 1, 2001; 164(7): 1253 - 1260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A J Carlisle and N C C Sharp Exercise and outdoor ambient air pollution Br. J. Sports Med., August 1, 2001; 35(4): 214 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-M. Hyvelin, J.-P. Savineau, and R. Marthan Plasticity in Skeletal, Cardiac, and Smooth Muscle: Selected Contribution: Effect of the aldehyde acrolein on acetylcholine-induced membrane current in airway smooth muscle cells J Appl Physiol, February 1, 2001; 90(2): 750 - 754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Foster, R. H. Brown, K. Macri, and C. S. Mitchell Bronchial reactivity of healthy subjects: 18-20 h postexposure to ozone J Appl Physiol, November 1, 2000; 89(5): 1804 - 1810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. FRISCHER, M. STUDNICKA, C. GARTNER, E. TAUBER, F. HORAK, A. VEITER, J. SPENGLER, J. KÜHR, and R. URBANEK Lung Function Growth and Ambient Ozone . A Three-Year Population Study in School Children Am. J. Respir. Crit. Care Med., August 1, 1999; 160(2): 390 - 396. [Abstract] [Full Text]
|
|
|
|
|
|
A. N. Passannante, M. J. Hazucha, P. A. Bromberg, E. Seal, L. Folinsbee, and G. Koch Nociceptive mechanisms modulate ozone-induced human lung function decrements J Appl Physiol, November 1, 1998; 85(5): 1863 - 1870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Ho and L.-Y. Lee Ozone enhances excitabilities of pulmonary C fibers to chemical and mechanical stimuli in anesthetized rats J Appl Physiol, October 1, 1998; 85(4): 1509 - 1515. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Roux, J.-M. Hyvelin, J.-P. Savineau, and R. Marthan Calcium Signaling in Airway Smooth Muscle Cells Is Altered by In Vitro Exposure to the Aldehyde Acrolein Am. J. Respir. Cell Mol. Biol., September 1, 1998; 19(3): 437 - 444. [Abstract] [Full Text]
|
|
|
|
|
|
I. ROMIEU, F. MENESES, M. RAMIREZ, S. RUIZ, R. P. PADILLA, J. J. SIENRA, M. GERBER, L. GRIEVINK, R. DEKKER, I. WALDA, et al. Antioxidant Supplementation and Respiratory Functions among Workers Exposed to High Levels of Ozone Am. J. Respir. Crit. Care Med., July 1, 1998; 158(1): 226 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. Joad, K. S. Kott, and A. C. Bonham Exposing guinea pigs to ozone for 1 wk enhances responsiveness of rapidly adapting receptors J Appl Physiol, April 1, 1998; 84(4): 1190 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. TORRES, M. J. UTELL, P. E. MOROW, K. Z. VOTER, J. C. WHITIN, C. COX, R. JOHN LOONEY, D. M. SPEERS, Y. TSAI, and M. W. FRAMPTON Airway Inflammation in Smokers and Nonsmokers with Varying Responsiveness to Ozone Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 728 - 736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. KRISHNA, D. SPRINGALL, Q.-H. MENG, N. WITHERS, D. MACLEOD, G. BISCIONE, A. FREW, J. POLAK, and S. HOLGATE Effects of Ozone on Epithelium and Sensory Nerves in the Bronchial Mucosa of Healthy Humans Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 943 - 950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Strom, L. Alfredsson, T. Malmfors, and O. Selroos Review : Ozone: Causation and Aggravation of Lung Diseases Indoor and Built Environment, March 1, 1994; 3(2): 69 - 78. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
