Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 67: 1512-1517, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frantz, E.
Right arrow Articles by Heymann, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frantz, E.
Right arrow Articles by Heymann, M. A.

Journal of Applied Physiology, Vol 67, Issue 4 1512-1517, Copyright © 1989 by American Physiological Society

ARTICLES

Bradykinin produces pulmonary vasodilation in fetal lambs: role of prostaglandin production

E. Frantz, S. J. Soifer, R. I. Clyman and M. A. Heymann
Cardiovascular Research Institute, University of California, San Francisco 94143.

Bradykinin produces pulmonary vasodilation and also stimulates production of other pulmonary vasodilators, including prostaglandin I2 (PGI2) and endothelial-derived relaxing factor. In 12 chronically instrumented fetal lambs, we therefore investigated potential mediation of the bradykinin response by PGI2 or other cyclooxygenase products. A 15-min infusion of bradykinin (approximately 1 microgram/kg estimated fetal wt/min) increased fetal pulmonary blood flow by 522% (P less than 0.05) and decreased pulmonary vascular resistance by 86% (P less than 0.05); plasma 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) concentration also increased (P less than 0.05). After cyclooxygenase inhibition by indomethacin (3 mg), bradykinin increased pulmonary blood flow by only 350% (P less than 0.05) and decreased pulmonary vascular resistance by 83% (P less than 0.05); plasma 6-keto-PGF1 alpha concentrations did not increase. The increase in pulmonary blood flow produced by bradykinin was greater before administration of indomethacin than after (P less than 0.05). These studies demonstrate that bradykinin produces fetal pulmonary vasodilation by at least two mechanisms, one dependent on and the other independent of PGI2 production, the latter mechanism predominating.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Houfflin-Debarge, A. Delelis, S. Jaillard, B. Larrue, P. Deruelle, A. S. Ducloy, F. Puech, and L. Storme
Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R547 - R553.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. L. Aschner, T. K. Smith, N. Kovacs, J. M. B. Pinheiro, and M. Fuloria
Mechanisms of bradykinin-mediated dilation in newborn piglet pulmonary conducting and resistance vessels
Am J Physiol Lung Cell Mol Physiol, August 1, 2002; 283(2): L373 - L382.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P.J Boels, J Deutsch, B Gao, and S.G Haworth
Perinatal development influences mechanisms of bradykinin-induced relaxations in pulmonary resistance and conduit arteries differently
Cardiovasc Res, July 1, 2001; 51(1): 140 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P.J. Boels, J. Deutsch, B. Gao, and S.G. Haworth
Maturation of the response to bradykinin in resistance and conduit pulmonary arteries
Cardiovasc Res, November 1, 1999; 44(2): 416 - 428.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online