Journal of Applied Physiology, Vol 67, Issue 4 1336-1340, Copyright © 1989 by American Physiological Society

ARTICLES

Contact phase of blood coagulation is not activated in edema of high altitude

P. Bartsch, B. Lammle, I. Huber, A. Haeberli, P. Vock, O. Oelz and P. W. Straub
Thrombosis Research Laboratory, University of Bern, Switzerland.

To examine whether bradykinin generated by the activation of the contact phase of blood coagulation is involved in the pathogenesis of edema occurring after acute exposure to high altitude, 15 mountaineers were examined at 490 m and 1, 3, and 5 days after arrival at 4,559 m. The clotting activity levels of factor XII, factor XI, plasma prekallikrein, and high-molecular-weight kininogen (HMWK) were measured, and plasma kallikrein-induced proteolytic cleavage of HMWK was assessed by ligand blotting by use of radiolabeled factor XI. After an ascent on foot from 1,170 to 4,559 m in 3 days, three subjects developed high-altitude pulmonary edema, and four subjects presented facial edema. There was no evidence for activation of the contact system in any subject as demonstrated by the lack of proteolytic cleavage of HMWK at high altitude. The absence of contact system activation was further supported by stable plasma levels of the individual factors of contact activation. Therefore, we conclude that bradykinin generated by plasma kallikrein-induced cleavage of HMWK is not involved in the pathogenesis of edema due to acute exposure to high altitude.

This article has been cited by other articles:

				T. Lehmann, H. Mairbaurl, B. Pleisch, M. Maggiorini, P. Bartsch, and W. H. Reinhart Platelet count and function at high altitude and in high-altitude pulmonary edema J Appl Physiol, February 1, 2006; 100(2): 690 - 694. [Abstract] [Full Text] [PDF]

				P. Bartsch, H. Mairbaurl, M. Maggiorini, and E. R. Swenson Physiological aspects of high-altitude pulmonary edema J Appl Physiol, March 1, 2005; 98(3): 1101 - 1110. [Abstract] [Full Text] [PDF]