Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 67: 1157-1163, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Georgopoulos, D.
Right arrow Articles by Anthonisen, N. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Georgopoulos, D.
Right arrow Articles by Anthonisen, N. R.

Journal of Applied Physiology, Vol 67, Issue 3 1157-1163, Copyright © 1989 by American Physiological Society

ARTICLES

Increased chemoreceptor output and ventilatory response to sustained hypoxia

D. Georgopoulos, S. Walker and N. R. Anthonisen
Department of Medicine, University of Manitoba, Winnipeg, Canada.

In adult humans the ventilatory response to sustained hypoxia (VRSH) is biphasic, characterized by an initial brisk increase, due to peripheral chemoreceptor (PC) stimulation, followed by a decline attributed to central depressant action of hypoxia. To study the effects of selective stimulation of PC on the ventilatory response pattern to hypoxia, the VRSH was evaluated after pretreatment with almitrine (A), a PC stimulant. Eight subjects were pretreated with A (75 mg po) or placebo (P) on 2 days in a single-blind manner. Two hours after drug administration, they breathed, in succession, room air (10 min), O2 (5 min), room air (5 min), hypoxia [25 min, arterial O2 saturation (SaO2) = 80%], O2 (5 min), and room air (5 min). End-tidal CO2 was kept constant at the normoxic base-line values. Inspiratory minute ventilation (VI) and breathing patterns were measured over the last 2 min of each period and during minutes 3-5 of hypoxia, and nadirs in VI were assessed just before and after O2 exposure. Independent of the day, the VRSH was biphasic. With P and A pretreatment, early hypoxia increased VI 4.6 +/- 1 and 14.2 +/- 1 (SE) l/min, respectively, from values obtained during the preceding room-air period. On A day the hypoxic ventilatory decline was significantly larger than that on P day, and on both days the decline was a constant fraction of the acute hypoxic response.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. J. Cummings and R. J. A. Wilson
Time-dependent modulation of carotid body afferent activity during and after intermittent hypoxia
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1571 - R1580.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Sajkov, A. Neill, N. A. Saunders, and R. D. McEvoy
Comparison of effects of sustained isocapnic hypoxia on ventilation in men and women
J Appl Physiol, August 1, 1997; 83(2): 599 - 607.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. GEORGOPOULOS, I. MITROUSKA, Z. BSHOUTY, K. WEBSTER, D. PATAKAS, and M. YOUNES
Respiratory Response to CO2 during Pressure-support Ventilation in Conscious Normal Humans
Am. J. Respir. Crit. Care Med., July 1, 1997; 156(1): 146 - 154.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
Y. Honda, H. Kimura, and M. Tanaka
Role of carotid body activity responsible for hypoxic ventilatory decline in awake humans
J Appl Physiol, January 1, 1997; 82(1): 371 - 371.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online