Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 67: 1093-1099, 1989;
8750-7587/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gutierrez, G.
Right arrow Articles by Marini, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gutierrez, G.
Right arrow Articles by Marini, C.

Journal of Applied Physiology, Vol 67, Issue 3 1093-1099, Copyright © 1989 by American Physiological Society

ARTICLES

Relationship of venous PO2 to muscle PO2 during hypoxemia

G. Gutierrez, N. Lund, A. L. Acero and C. Marini
Division of Pulmonary Medicine, University of Texas Health Science Center, Houston 77030.

Anesthetized mechanically ventilated rabbits were subjected to progressive hypoxemia (n = 7) to determine the relationship of venous PO2 (PvO2) to skeletal muscle PO2 (PtiO2). Measures of arterial PO2 (PaO2), right atrial PO2 [(PvO2)RA], and hindlimb PO2 [(PvO2)limb], were obtained from the carotid artery, right atrium, and inferior vena cava, just above the level of the iliac bifurcation. Biceps femoris muscle PtiO2 was measured with a surface O2 microelectrode having eight measuring points. PaO2 was decreased from 90.3 +/- 5.4 to 26.8 +/- 0.8 Torr in five consecutive steps, followed by reoxygenation to 105.6 +/- 10.5 (SE) Torr. Measurements were obtained after each decrement in PaO2. A total of 128 measures of PtiO2 were obtained per experimental stage. The mean and distribution of the muscle PtiO2 histogram were determined. Measurements were compared with analysis of variance and the Newman-Keuls post hoc method. (PvO2)limb had similar values as the average muscle PtiO2 (PtiO2) for PaO2 values greater than 52.1 +/- 4.3 Torr, where (PvO2)limb became greater than PtiO2 (P less than 0.05). The lowest measures of (PvO2)limb and PtiO2 were 15.9 +/- 0.7 and 4.0 +/- 0.1 Torr, respectively (P less than 0.01). The PtiO2 histograms showed no evidence of increased microvascular heterogeneity with hypoxemia. We conclude that in hypoxemia PvO2 is greater than muscle PtiO2. This difference may be related to the establishment of significant physicochemical O2 gradients from erythrocyte to tissue cell.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
J. T. Williams, M. P. Pricher, and J. R. Halliwill
Is postexercise hypotension related to excess postexercise oxygen consumption through changes in leg blood flow?
J Appl Physiol, April 1, 2005; 98(4): 1463 - 1468.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. A. Guzman, A. E. Rosado, and J. A. Kruse
Dopamine-1 receptor stimulation impairs intestinal oxygen utilization during critical hypoperfusion
Am J Physiol Heart Circ Physiol, February 1, 2003; 284(2): H668 - H675.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
P.-O. Joachimsson, F. Sjoberg, M. Forsman, M. Johansson, H. C. Ahn, and H. Rutberg
ADVERSE EFFECTS OF HYPEROXEMIA DURING CARDIOPULMONARY BYPASS
J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 812 - 819.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online